Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 10/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.60 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.60 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2314510 | 0.90 | FTO (0.60) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL84112 | 0.89 | FTO (0.59) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL2184643 | 0.89 | FTO (0.59) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL336896 | 0.89 | FTO (0.59) | FTOMAPTHPGDMEN1HTT | |
| Hydrochloric Acid SCHEMBL7640824 | 0.88 | FTO (0.57) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL16116120 | 0.87 | FTO (0.54) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL4825622 | 0.86 | FTO (0.56) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL22110384 | 0.86 | FTO (0.56) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL1115891 | 0.86 | HPGD (0.57) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL7647553 | 0.86 | FTO (0.56) | FTOMAPTHPGDMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084627-B2 | obtained the compound by reducing the carboxy-ester to an alcohol; non-interact with positively charged biomolecules; cell-permeable, water soluble, easily synthesized from commercially available materials; conjugated yellow or green pigments with biomolecule protein or nucleic acids | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2011-12-27 | — | — | US | disclosed |
| US-8084627-B2 | obtained the compound by reducing the carboxy-ester to an alcohol; non-interact with positively charged biomolecules; cell-permeable, water soluble, easily synthesized from commercially available materials; conjugated yellow or green pigments with biomolecule protein or nucleic acids | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2011-12-27 | — | — | US | disclosed |
| US-20080275257-A1 | Hydroxymethyl fluorescein derivatives for use as biological markers and dyes | PITTSBURGH, UNIVERSITY OF | 2008-11-06 | — | — | US | disclosed |
| US-20080275257-A1 | Hydroxymethyl fluorescein derivatives for use as biological markers and dyes | PITTSBURGH, UNIVERSITY OF | 2008-11-06 | — | — | US | disclosed |
| WO-2008094502-A1 | HYDROXYMETHYL FLUORESCEIN DERIVATIVES FOR USE AS BIOLOGICAL MARKERS AND DYES | UNIVERSITY OF PITTSBURGH (US) | 2008-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275257-A1 | Hydroxymethyl fluorescein derivatives for use as biological markers and dyes | DHFR, CD44, MGMT | FTO 443/4885MAPT 3728/4885HPGD 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.