Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 4/20 | 0.34 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8721646 | 0.86 | PIM1 (0.35) | CYP2C9CYP2C19CA1CA2TPSAB1 | |
| SCHEMBL3672272 | 0.84 | CYP2C9 (0.48) | CYP2C9CYP2C19CA1CA2CA12 | |
| SCHEMBL6682075 | 0.80 | ST14 (0.45) | CA1CA2CA12CA9TPSAB1 | |
| SCHEMBL6465799 | 0.79 | CYP2C9 (0.60) | CYP2C9CYP2C19TPSAB1GAAPRSS1 | |
| SCHEMBL16181585 | 0.79 | NOS1 (0.52) | CYP2C9CYP2C19CA1CA2TPSAB1 | |
| SCHEMBL45768 | 0.78 | CA12 (0.57) | CYP2C9CYP2C19CA1CA2CA12 | |
| SCHEMBL6770565 | 0.77 | CA12 (0.35) | CYP2C9CYP2C19CA1CA2CA12 | |
| SCHEMBL14686209 | 0.77 | TPSAB1 (0.59) | CYP2C9CYP2C19TPSAB1ST14PRSS1 | |
| SCHEMBL6881708 | 0.77 | EPHX2 (0.45) | CYP2C9CYP2C19TPSAB1ST14ALDH1A1 | |
| SCHEMBL6881703 | 0.77 | CYP2C9 (0.42) | CYP2C9CYP2C19CA1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 163 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110165700-A1 | CLASSES OF COMPOUNDS THAT INTERACT WITH INTEGRINS | ALCHEMIA LIMITED (AU) | 2011-07-07 | — | — | US | claimed |
| EP-1843760-A4 | CLASSES OF COMPOUNDS THAT INTERACT WITH INTEGRINS | ALCHEMIA LTD (AU) | 2009-03-25 | — | — | EP | claimed |
| US-20080176936-A1 | Classes of Compounds that Interact with Integrins | ALCHEMIA LIMITED (AU) | 2008-07-24 | — | — | US | claimed |
| EP-1843760-A1 | CLASSES OF COMPOUNDS THAT INTERACT WITH INTEGRINS | Alchemia Pty Ltd (AU) | 2007-10-17 | — | — | EP | claimed |
| WO-2006081616-A1 | CLASSES OF COMPOUNDS THAT INTERACT WITH INTEGRINS | ALCHEMIA LIMITED (AU) | 2006-08-10 | — | — | WO | claimed |
| US-5723480-A | Adhesion receptor antagonists III | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-03 | — | — | US | claimed |
| US-5627197-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-05-06 | — | — | US | claimed |
| US-5532255-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | claimed |
| EP-0171037-B1 | 3-CARBONYL-1-AMINOALKYL-1H-INDOLES USEFUL AS ANALGESICS AND PREPARATION THEREOF | STERLING WINTHROP INC. (US) | 1992-06-17 | — | — | EP | claimed |
| US-5013732-A | Analgesics | STERLING DRUG INC. (US) | 1991-05-07 | — | — | US | claimed |
| US-4581354-A | ANALGESICS;ANTI-RHEUMATIC AND ANTI-INFLAMMATORY AGENTS | STERLING DRUG INC. (US) | 1986-04-08 | — | — | US | claimed |
| EP-0171037-A2 | 3-Carbonyl-1-aminoalkyl-1H-indoles useful as analgesics and preparation thereof | STERLING WINTHROP INC. (US) | 1986-02-12 | — | — | EP | claimed |
| US-4342869-A | Cephalosporin antibiotics | MERCK & CO., INC. (US) | 1982-08-03 | — | — | US | claimed |
| US-4342757-A | Cephalosporin antibiotic compositions | MERCK & CO., INC. (US) | 1982-08-03 | — | — | US | claimed |
| US-4338437-A | Cephalosporin antibiotics | MERCK & CO., INC. (US) | 1982-07-06 | — | — | US | claimed |
| US-4338438-A | Cephalosporin antibiotics | MERCK & CO., INC. (US) | 1982-07-06 | — | — | US | claimed |
| US-4310459-A | Process for producing carbamoyl substituted penams and carbamoyl substituted cephams from penicillin sulfoxide esters | BRISTOL-MYERS COMPANY (US) | 1982-01-12 | — | — | US | claimed |
| US-4298741-A | DETHIAPENICILLIN ANTIBIOTICS | MERCK & CO., INC. (US) | 1981-11-03 | — | — | US | claimed |
| US-4297488-A | 7-α-Methoxy cephalosporins | MERCK & CO., INC. (US) | 1981-10-27 | — | — | US | claimed |
| US-4060687-A | Cephalosporins having a 3-α substituted alkyl grouping | MERCK & CO., INC. (US) | 1977-11-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176936-A1 | Classes of Compounds that Interact with Integrins | ITGB3, ITGB5, ITGA5 | CYP2C9 2600/4885CYP2C19 3176/4885CA1 3985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.