Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30366178 | 1.00 | F2RL1 (0.32) | F2RL1KDM4EMAPK1HSD17B10ALDH1A1 | |
| SCHEMBL18175598 | 0.81 | ALDH1A1 (0.37) | F2RL1ALDH1A1 | |
| SCHEMBL17189716 | 0.81 | KDM4E (0.42) | KDM4EMAPK1HSD17B10ALDH1A1 | |
| SCHEMBL16769033 | 0.78 | KCNH2 (0.37) | F2RL1KDM4EMAPK1HSD17B10ALDH1A1 | |
| SCHEMBL20618754 | 0.78 | — | — | |
| SCHEMBL17189714 | 0.75 | KDM4E (0.40) | KDM4EMAPK1HSD17B10ALDH1A1 | |
| SCHEMBL18911208 | 0.74 | NPSR1 (0.46) | F2RL1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL22420470 | 0.74 | MEN1 (0.32) | — | |
| SCHEMBL19466353 | 0.74 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL17189713 | 0.74 | L3MBTL1 (0.39) | KDM4EMAPK1HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110770219-B | Derivatives of dibenzofuran and dibenzothiophene | 默克专利股份有限公司 | 2023-04-21 | — | — | CN | disclosed |
| EP-3638657-B1 | DIBENZOFURAN DERIVATIVES AND DIBENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2022-07-20 | — | — | EP | disclosed |
| US-11236063-B2 | Dibenzofuran derivatives and dibenzothiophene derivatives | MERCK PATENT GMBH (DE) | 2022-02-01 | — | — | US | disclosed |
| US-11236063-B2 | Dibenzofuran derivatives and dibenzothiophene derivatives | MERCK PATENT GMBH (DE) | 2022-02-01 | — | — | US | disclosed |
| US-20210139451-A1 | DIBENZOFURAN DERIVATIVES AND DIBENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2021-05-13 | — | — | US | disclosed |
| US-20210139451-A1 | DIBENZOFURAN DERIVATIVES AND DIBENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2021-05-13 | — | — | US | disclosed |
| EP-3638657-A1 | DIBENZOFURAN DERIVATIVES AND DIBENZOTHIOPHENE DERIVATIVES | Merck Patent GmbH (DE) | 2020-04-22 | — | — | EP | disclosed |
| CN-110770219-A | Dibenzofurane and dibenzothiophene derivatives | 默克专利股份有限公司 | 2020-02-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11236063-B2 | Dibenzofuran derivatives and dibenzothiophene derivatives | DDT, EDF1, DBF4 | F2RL1 2629/4885KDM4E 4161/4885MAPK1 1754/4885 |
| US-20210139451-A1 | DIBENZOFURAN DERIVATIVES AND DIBENZOTHIOPHENE DERIVATIVES | DDT, DBF4, EDF1 | F2RL1 2809/4885KDM4E 3394/4885MAPK1 991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.