TXNRD3

Thioredoxin reductase 3 · Q86VQ6 · TXNRD3 on Sugi Atlas →

9,213 patent compounds predicted against TXNRD3, 6,359 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Gamma-Cyclodextrin (SCHEMBL8768)	0.77	6/20
Betadex (SCHEMBL24215)	0.77	6/20
Alfadex (SCHEMBL24981)	0.77	6/20
Betadex (SCHEMBL127367)	0.77	6/20
Gamma-Cyclodextrin (SCHEMBL180792)	0.77	6/20
Alfadex (SCHEMBL181370)	0.77	6/20
Betadex (SCHEMBL434559)	0.77	6/20
SCHEMBL466130	0.77	6/20
Betadex (SCHEMBL692932)	0.74	6/20
Betadex (SCHEMBL1395831)	0.74	6/20
Betadex (SCHEMBL441667)	0.61	6/20
SCHEMBL890314	0.59	6/20
SCHEMBL1193222	0.59	6/20
SCHEMBL398655	0.53	6/20
SCHEMBL432885	0.53	6/20
SCHEMBL1056613	0.53	6/20
SCHEMBL1614698	0.51	6/20
Betadex (SCHEMBL193191)	0.50	6/20
Betadex (SCHEMBL306328)	0.49	6/20
SCHEMBL8265	0.43	6/20

Clinical trials — most relevant to TXNRD3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Role of Vitamin E in Gaucher Disease Patients	PHASE3	COMPLETED
Effect of Pioglitazone Administered to Patients With Friedreich's Ataxia: Proof of Concept	PHASE3	COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Effect of Melatonin in Patients With Diabetic Peripheral Neuropathy	PHASE2	RECRUITING
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients	PHASE2	COMPLETED
Broccoli Sprout Extracts Trial to See if NRF2 is Enhanced by Sulforaphane Treatment in Patients With COPD	PHASE2	COMPLETED
Clinical Trial of 2-HOBA in Pulmonary Arterial Hypertension	PHASE2	NOT_YET_RECRUITING
SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS)	PHASE1/PHASE2	COMPLETED
Tolerability of Enteral NAC in Infants	PHASE1	NOT_YET_RECRUITING
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease	EARLY_PHASE1	RECRUITING
Macrophage Migration Inhibitory Factor (MIF)- Cardiac Surgery	nan	COMPLETED
Correlation Research of Thioredoxin Reductase in Lung Cancer	nan	COMPLETED
Thiol/Disulphide Homeostasis in Unexplained Infertility	nan	COMPLETED
Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)	nan	RECRUITING
Effects of Preoperative Oral Carbohydrate Loading on Maternal Thiol-disulfide Homeostasis	nan	COMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise	nan	COMPLETED
Human Study of Hydroxytyrosol on Phase II Enzymes in Healthy Subjects	nan	COMPLETED
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults	nan	COMPLETED
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients	nan	UNKNOWN
Tecfidera Diffusion Tensor Imaging	nan	COMPLETED
Genetic Association of Diabetic Retinopathy-1	nan	UNKNOWN
Evaluation of Mitochondrial Enzyme Activity in Cesarean Section Patients	nan	UNKNOWN
Effect of Supplementary Vitamins on Oxidant Gene Expression in the Lungs of Healthy Smokers	nan	COMPLETED
Thermogenic Silencer Regulatory Factors in Humans	nan	ACTIVE_NOT_RECRUITING
Molecular Epidemiology of Parkinson's Disease	nan	COMPLETED
Genetic Determinants of Congenital Heart Disease Outcomes	nan	COMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse	nan	ACTIVE_NOT_RECRUITING
The Curative Effect of Entecavir Combined Resveratrol on HBV patients-a Multi-center, Random, Open Clinical Trial	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TXNRD3 binder may also engage these)

Protein	Name	Similarity
Q99MD6	—	0.999	Q99MD6 →
TXNRD1	Thioredoxin reductase 1, cytoplasmic	0.998	landscape →
O62768	—	0.990	O62768 →
O89049	—	0.989	O89049 →
P91938	—	0.989	P91938 →
Q9JMH6	—	0.987	Q9JMH6 →
TXNRD2	Thioredoxin reductase 2, mitochondrial	0.987	landscape →
GSR	Glutathione reductase, mitochondrial	0.987	landscape →
Q9JLT4	—	0.987	Q9JLT4 →
P39050	—	0.987	P39050 →
Q5NVA2	—	0.987	Q5NVA2 →
Q17745	—	0.987	Q17745 →
P28593	—	0.986	P28593 →
P27456	—	0.986	P27456 →
A2TIL1	—	0.985	A2TIL1 →
P39051	—	0.985	P39051 →
Q9MYY8	—	0.985	Q9MYY8 →
P13110	—	0.985	P13110 →
Q43154	—	0.985	Q43154 →
P42770	—	0.984	P42770 →
A8MS68	—	0.984	A8MS68 →
Q9VNT5	—	0.984	Q9VNT5 →
Q25861	—	0.984	Q25861 →
P30635	—	0.984	P30635 →
Q9Z0J5	—	0.983	Q9Z0J5 →
P80461	—	0.983	P80461 →
Q9LK94	—	0.983	Q9LK94 →
P00927	—	0.983	P00927 →
F4JLP5	—	0.983	F4JLP5 →
P48642	—	0.983	P48642 →