Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186762 | 0.87 | POLB (0.50) | POLBDHODHKDM4EKMT2AMAOB | |
| SCHEMBL2187905 | 0.84 | L3MBTL1 (0.49) | POLBKDM4EKMT2ALMNAALDH1A1 | |
| SCHEMBL2185780 | 0.80 | POLB (0.50) | POLBKDM4EKMT2AMAOBHTT | |
| SCHEMBL2189405 | 0.78 | KDM4E (0.49) | POLBKDM4EKMT2AHTTLMNA | |
| SCHEMBL9001638 | 0.78 | POLB (0.75) | POLBKDM4EKMT2AMAOBHTT | |
| SCHEMBL69159 | 0.73 | ALDH1A1 (0.58) | POLBDHODHKDM4EKMT2ANPSR1 | |
| SCHEMBL5234734 | 0.73 | HTT (0.41) | POLBKDM4EKMT2AHTTALDH1A1 | |
| SCHEMBL2186765 | 0.73 | KMT2A (0.43) | POLBKDM4EKMT2AHTTNPSR1 | |
| SCHEMBL11129083 | 0.72 | CES2 (0.53) | POLBKDM4EKMT2AHTTLMNA | |
| SCHEMBL3621051 | 0.72 | DHODH (0.51) | POLBDHODHKDM4EKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578741-B1 | AROMATIC COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS | 4SC AG (DE) | 2011-07-13 | — | — | EP | claimed |
| EP-1578741-B1 | AROMATIC COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |