Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 3/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 9/20 | 0.36 |
| ▸ | SGK1 | O00141 | 1/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4811891 | 0.83 | MKNK1 (0.52) | CDC7GPR52MKNK1MKNK2BTK | |
| SCHEMBL4552526 | 0.81 | MKNK1 (0.38) | CDC7MKNK1MKNK2BTK | |
| SCHEMBL21857459 | 0.73 | KDM4E (0.38) | — | |
| SCHEMBL28940758 | 0.72 | GPR52 (0.42) | HSD17B1CDC7GPR52MKNK1MKNK2 | |
| SCHEMBL4437714 | 0.72 | CHUK (0.59) | HSD17B1CDC7MKNK1MKNK2 | |
| SCHEMBL21856932 | 0.71 | TSHR (0.40) | — | |
| SCHEMBL30268344 | 0.71 | TSHR (0.40) | — | |
| SCHEMBL3783154 | 0.70 | PRKCI (0.43) | HSD17B1CDC7PARP1GABRPGABRD | |
| SCHEMBL4109320 | 0.69 | HSD17B1 (0.39) | HSD17B1CDC7GPR52MKNK1MKNK2 | |
| SCHEMBL20113065 | 0.69 | GPR52 (0.46) | HSD17B1GPR52MKNK1MKNK2SGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346825-A2 | MODULATORS OF P2X3 RECEPTOR ACTIVITY | Evotec AG (DE) | 2011-07-27 | — | — | EP | claimed |
| WO-2010033168-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2010-03-25 | — | — | WO | claimed |