Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.38 |
| ▸ | BTK | Q06187 | 8/20 | 0.36 |
| ▸ | CHUK | O15111 | 3/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.35 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 3/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4811891 | 0.84 | MKNK1 (0.52) | MKNK1MKNK2BTKCDC7 | |
| SCHEMBL2185846 | 0.81 | HSD17B1 (0.42) | MKNK1MKNK2BTKCDC7 | |
| SCHEMBL2552512 | 0.80 | BCAT2 (0.49) | BTKBCAT2CDC7 | |
| SCHEMBL21857459 | 0.76 | KDM4E (0.38) | — | |
| SCHEMBL4367850 | 0.73 | LRRK2 (0.34) | — | |
| SCHEMBL4554108 | 0.73 | KEAP1 (0.44) | BTKBCAT2 | |
| SCHEMBL30268344 | 0.72 | TSHR (0.40) | — | |
| SCHEMBL21856932 | 0.72 | TSHR (0.40) | — | |
| SCHEMBL13411815 | 0.70 | POLB (0.33) | MKNK1MKNK2 | |
| SCHEMBL14414911 | 0.67 | TP53 (0.44) | MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134175-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121786-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-09 | — | — | WO | disclosed |