Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21861602 | 0.86 | TRPA1 (0.41) | TRPA1RXFP1 | |
| SCHEMBL21861448 | 0.77 | TRPA1 (0.45) | TRPA1 | |
| SCHEMBL21861443 | 0.71 | — | — | |
| SCHEMBL7988189 | 0.66 | ADORA2A (0.42) | ADORA2A | |
| SCHEMBL10280149 | 0.65 | TRPA1 (0.36) | TRPA1RXFP1 | |
| SCHEMBL15384375 | 0.64 | TRPA1 (0.37) | TRPA1RXFP1 | |
| SCHEMBL21861317 | 0.63 | TRPA1 (0.61) | TRPA1 | |
| SCHEMBL7985623 | 0.63 | ADORA2A (0.45) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL18175174 | 0.63 | ADORA2A (0.42) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL14006396 | 0.62 | ALDH1A1 (0.43) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193880-B1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | LILLY CO ELI (US) | 2020-03-25 | — | — | EP | disclosed |