Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | TSHR | P16473 | 7/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15457190 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2HTTCYP2D6CYP1A2CYP3A4 | |
| SCHEMBL2178309 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2HTTCYP2D6CYP1A2CYP3A4 | |
| SCHEMBL638079 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2HTTCYP2D6CYP1A2CYP3A4 | |
| SCHEMBL12409984 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2HTTCYP2D6CYP1A2CYP3A4 | |
| SCHEMBL2176769 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2HTTCYP2D6CYP1A2CYP3A4 | |
| SCHEMBL2182238 | 0.74 | ALDH1A1 (0.48) | SMN1; SMN2HTTCYP2D6CYP1A2CYP3A4 | |
| SCHEMBL1620437 | 0.71 | NUDT1 (0.62) | SMN1; SMN2HTTCYP2D6CYP1A2CYP3A4 | |
| SCHEMBL12261791 | 0.71 | SMN1; SMN2 (0.61) | SMN1; SMN2HTTCYP2D6CYP1A2CYP3A4 | |
| SCHEMBL14606873 | 0.71 | PDE10A (0.49) | SMN1; SMN2HTTCYP2D6CYP1A2CYP3A4 | |
| SCHEMBL14606606 | 0.70 | PDE10A (0.51) | SMN1; SMN2HTTCYP2D6CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342191-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | Mitsubishi Tanabe Pharma Corporation (JP) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010030027-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-03-18 | — | — | WO | disclosed |