Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3528016 | 0.91 | ALDH1A1 (0.43) | PDE2A | |
| SCHEMBL2186994 | 0.91 | GLS (0.42) | SCN9ASCN5AKCNH2 | |
| SCHEMBL3524286 | 0.90 | ELANE (0.42) | SLC22A2 | |
| SCHEMBL3523992 | 0.89 | SLC22A2 (0.47) | SLC22A2 | |
| SCHEMBL2186951 | 0.88 | SLC22A2 (0.41) | SLC22A2 | |
| SCHEMBL2186878 | 0.87 | MEN1 (0.39) | EPHX2NR1H4SLC22A2 | |
| SCHEMBL3529763 | 0.85 | SLC22A2 (0.43) | SLC22A2 | |
| SCHEMBL2185146 | 0.85 | P2RX7 (0.47) | SLC22A2 | |
| SCHEMBL2186862 | 0.84 | SLC22A2 (0.46) | SLC22A2 | |
| SCHEMBL2185365 | 0.84 | PDE2A (0.45) | PDE2AEPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1852434-B1 | BICYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITING ACTIVITY | SHIONOGI & CO (JP) | 2011-07-13 | — | — | EP | disclosed |
| US-7858788-B2 | Bicyclic carbamoylpyridone derivative having HIV integrase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2010-12-28 | — | — | US | disclosed |
| EP-1852434-A1 | BICYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITING ACTIVITY | Shionogi Co., Ltd. (JP) | 2007-11-07 | — | — | EP | disclosed |