Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 3/20 | 0.36 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.35 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2185877 | 0.90 | CFD (0.44) | CYP4F2CYP4A11CHRNB2CHRNA4MEN1 | |
| SCHEMBL2185728 | 0.81 | BACE1 (0.34) | CYP4F2CYP4A11CHRNB2CHRNA4CDK8 | |
| SCHEMBL2185662 | 0.79 | MEN1 (0.40) | MEN1HTTGFERKMT2AHSD17B10 | |
| SCHEMBL2184830 | 0.76 | CHRNB2 (0.40) | CHRNB2CHRNA4MEN1HTTGFER | |
| SCHEMBL2307750 | 0.75 | AKT1 (0.38) | CHRNB2CHRNA4CDK8AKT1 | |
| SCHEMBL2186290 | 0.74 | CHRNB2 (0.46) | CYP4F2CYP4A11CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL2185542 | 0.74 | AKT1 (0.36) | CHRNB2CHRNA4AKT1SLC5A1CHRNB4 | |
| SCHEMBL3358712 | 0.73 | AKT1 (0.38) | AKT1SLC5A1 | |
| SCHEMBL7409828 | 0.73 | P4HTM (0.41) | DDB1CRBN | |
| SCHEMBL7412039 | 0.71 | P4HTM (0.39) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342192-A2 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF | Psychogenics Inc. (US) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010045212-A2 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF | PSYCHOGENICS, INCSTATUTS (US) | 2010-04-22 | — | — | WO | disclosed |