SCHEMBL2186299

SCHEMBL2186299

CCCC(C)(C)Nc1ccc(Nc2ccccc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.48
ALOX12 P18054 7/20 0.48
HSD17B10 Q99714 5/20 0.48
L3MBTL1 Q9Y468 4/20 0.48
ALOX15 P16050 3/20 0.48
TSHR P16473 3/20 0.48
MAPK1 P28482 3/20 0.48
TDP1 Q9NUW8 2/20 0.48
PTGS1 P23219 1/20 0.48
SLC6A2 P23975 1/20 0.48
PTGS2 P35354 1/20 0.48
HTR2B P41595 1/20 0.48
HPGD P15428 5/20 0.45
MAPT P10636 10/20 0.45
GAA P10253 5/20 0.44
RAB9A P51151 1/20 0.44
NPSR1 Q6W5P4 1/20 0.42
CYP3A4 P08684 5/20 0.41
LMNA P02545 1/20 0.41
THRB P10828 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1453847 0.92 GAA (0.43) ALDH1A1ALOX12HSD17B10TSHRTDP1
SCHEMBL21634339 0.89 MAPT (0.46) ALDH1A1ALOX12HSD17B10L3MBTL1ALOX15
SCHEMBL11726260 0.88 MAPT (0.44) ALDH1A1ALOX12HSD17B10L3MBTL1ALOX15
SCHEMBL11727638 0.85 ALDH1A1 (0.52) ALDH1A1ALOX12HSD17B10L3MBTL1ALOX15
SCHEMBL8060012 0.83 ALDH1A1 (0.51) ALDH1A1ALOX12HSD17B10L3MBTL1ALOX15
SCHEMBL29569965 0.82 MAPT (0.41) ALDH1A1ALOX12HSD17B10L3MBTL1ALOX15
SCHEMBL2445813 0.80 ALDH1A1 (0.62) ALDH1A1ALOX12HSD17B10L3MBTL1ALOX15
SCHEMBL1454677 0.79 GAA (0.47) ALDH1A1ALOX12MAPK1MAPTGAA
SCHEMBL11726250 0.79 ALDH1A1 (0.50) ALDH1A1ALOX12HSD17B10L3MBTL1ALOX15
SCHEMBL13091135 0.79 GAA (0.45) ALDH1A1HSD17B10L3MBTL1ALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10696618-B2 Nitroxide hydroxylamine and phenylenediamine combinations as polymerization inhibitors for ethylenically unsaturated monomer processes ECOLAB USA INC. (US) 2020-06-30 US claimed
US-20190241496-A1 NITROXIDE HYDROXYLAMINE AND PHENYLENEDIAMINE COMBINATIONS AS POLYMERIZATION INHIBITORS FOR ETHYLENICALLY UNSATURATED MONOMER PROCESSES Ecolab USA, Inc. (US) 2019-08-08 US claimed
US-20190023642-A1 NITROXIDE HYDROXYLAMINE AND PHENYLENEDIAMINE COMBINATIONS AS POLYMERIZATION INHIBITORS FOR ETHYLENICALLY UNSATURATED MONOMER PROCESSES Ecolab USA, Inc. (US) 2019-01-24 US claimed
WO-2024145438-A1 CURED EPOXY RESIN AND METHOD OF CURING AN EPOXY RESIN USING AN AMINE COMPOUND SI GROUP, INC. (US) 2024-07-04 WO disclosed
CN-118032800-A Terahertz Characterization of Multi-Layer Tire Tread 固特异轮胎和橡胶公司 2024-05-14 CN disclosed
US-20240102926-A1 TERAHERTZ CHARACTERIZATION OF A MULTI-LAYERED TIRE TREAD THE GOODYEAR TIRE & RUBBER COMPANY 2024-03-28 US disclosed
EP-4331821-A1 METHOD AND APPARATUS FOR TERAHERTZ CHARACTERIZATION OF A MULTI-LAYERED TIRE TREAD The Goodyear Tire & Rubber Company (US) 2024-03-06 EP disclosed
US-11874223-B1 Terahertz characterization of a multi-layered tire tread THE GOODYEAR TIRE & RUBBER COMPANY (US) 2024-01-16 US disclosed
US-20200369854-A1 RUBBER COMPOSITION AND HOSE THE YOKOHAMA RUBBER CO., LTD. (JP) 2020-11-26 US disclosed
EP-3611223-A1 RUBBER COMPOSITION AND HOSE The Yokohama Rubber Co., Ltd. (JP) 2020-02-19 EP disclosed
US-8980392-B2 Use of a specific functionalised organosilicon compound as a coupling agent in an isoprene elastomer composition including a reinforcing inorganic filler RHODIA OPERATIONS (FR) 2015-03-17 US disclosed
US-5344861-A Polymer blend with organic acid, phenylamine, phenylenediamine and acid acceptor with vulcanization agent TOSOH CORPORATION (JP) 1994-09-06 US disclosed
WO-1994001493-A1 METHOD AND COMPOSITION FOR USING SUBSTITUTED MELAMINES AS NOVOLAK RESIN CURING AGENTS COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN - MICHELIN & CIE (FR) 1994-01-20 WO disclosed
EP-0413305-A1 Chlorosulfonated polyethylene polymer composition TOSOH CORPORATION (JP) 1991-02-20 EP disclosed
US-4525430-A HIGH ELECTRICAL RESISTANCE N.V. BEKAERT S.A., A CORP. OF BELGIUM (BE) 1985-06-25 US disclosed
EP-0118941-A1 Steel fibre reinforced rubber article N.V. BEKAERT S.A. (BE) 1984-09-19 EP disclosed
US-4396052-A SANDWICH LAYER OF VULCANIZED BLENDS OF 1,3-BUTADIENE-METHYLALLENE POLYMER AND NATURAL RUBBER OR POLYISOPRENE THE YOKOHAMA RUBBER CO., LTD. (JP) 1983-08-02 US disclosed
US-4355068-A Impregnated gasket and method of producing GOETZE AG (DE) 1982-10-19 US disclosed
US-4347290-A HAVING AN ADHESIVE COATING OF A BRASS ALLOY CONTAINING COBALT N.V. BEKAERT S.A. (BE) 1982-08-31 US disclosed
US-4255496-A Steel wire reinforcing elements with a brass-cobalt alloy adhesive coating N. V. BEKAERT S.A. (BE) 1981-03-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10696618-B2 Nitroxide hydroxylamine and phenylenediamine combinations as polymerization inhibitors for ethylenically unsaturated monomer processes PNMT, NOS1, HPGD ALDH1A1 201/4885ALOX12 138/4885HSD17B10 331/4885
US-20190023642-A1 NITROXIDE HYDROXYLAMINE AND PHENYLENEDIAMINE COMBINATIONS AS POLYMERIZATION INHIBITORS FOR ETHYLENICALLY UNSATURATED MONOMER PROCESSES PNMT, NOS1, HPGD ALDH1A1 201/4885ALOX12 138/4885HSD17B10 331/4885
US-20190241496-A1 NITROXIDE HYDROXYLAMINE AND PHENYLENEDIAMINE COMBINATIONS AS POLYMERIZATION INHIBITORS FOR ETHYLENICALLY UNSATURATED MONOMER PROCESSES PNMT, NOS1, HPGD ALDH1A1 201/4885ALOX12 138/4885HSD17B10 331/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.