Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 5/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | LSS | P48449 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6310151 | 0.75 | PARP10 (0.65) | PARP10 | |
| SCHEMBL21864624 | 0.74 | HTR1D (0.38) | RXRA | |
| SCHEMBL17888657 | 0.72 | PARP10 (0.42) | RARBPARP10CYP2C9 | |
| SCHEMBL21864622 | 0.71 | MAPT (0.38) | — | |
| SCHEMBL17899401 | 0.69 | SLC6A2 (0.41) | CHEK2RARBPARP10 | |
| SCHEMBL21864643 | 0.69 | HPGD (0.43) | RARBCYP2C9 | |
| SCHEMBL21864626 | 0.68 | GSK3B (0.49) | CHEK2RARBPARP10 | |
| SCHEMBL24572422 | 0.67 | CHEK2 (0.43) | CHEK2PARP10CHEK1CYP2C9FYN | |
| SCHEMBL12390490 | 0.67 | SLC9A1 (0.45) | CHEK2PARP10 | |
| SCHEMBL578814 | 0.67 | CHEK2 (0.49) | CHEK2RARBPARP10CHEK1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020071550-A1 | CDK8 INHIBITOR AND USE OF SAME | 京都薬品工業株式会社 | 2020-04-09 | — | — | WO | disclosed |