Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21697489 | 0.87 | PARP10 (0.45) | SLC6A2SLC6A4MAOBPARP10MAPT | |
| SCHEMBL17888657 | 0.84 | PARP10 (0.42) | SLC6A2SLC6A4PARP10MAPTKDM4E | |
| SCHEMBL6310151 | 0.76 | PARP10 (0.65) | MAOBPARP10MAPTPRSS1MAPK1 | |
| SCHEMBL17899375 | 0.75 | CHEK2 (0.39) | SLC6A2SLC6A4MAOBPARP10MAPT | |
| SCHEMBL21697477 | 0.74 | PARP10 (0.54) | SLC6A2SLC6A4MAOBPARP10MAPT | |
| SCHEMBL17888521 | 0.72 | ICAM1 (0.41) | SLC6A2SLC6A4MAOBPARP10KDM4E | |
| SCHEMBL21864684 | 0.69 | CHEK2 (0.41) | PARP10CHEK2RARB | |
| SCHEMBL17899369 | 0.69 | SLC6A2 (0.38) | SLC6A2SLC6A4PARP10MAPTKDM4E | |
| SCHEMBL23395406 | 0.69 | LMNA (0.39) | PARP10MAPTKDM4ESMN1; SMN2TSHR | |
| SCHEMBL6135839 | 0.68 | THRA (0.49) | SLC6A2SLC6A4MAOBKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11013728-B2 | Cyclin-dependent kinase 8 and/or 19 inhibitor | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2021-05-25 | — | — | US | disclosed |
| US-20210100783-A1 | NOVEL CYCLIN-DEPENDENT KINASE 8 AND/OR 19 INHIBITOR | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2021-04-08 | — | — | US | disclosed |
| EP-3607944-A1 | NOVEL CYCLIN-DEPENDENT KINASE 8 AND/OR 19 INHIBITOR | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2020-02-12 | — | — | EP | disclosed |
| US-20160207883-A1 | NOVEL AROMATIC COMPOUND AND USE THEREOF | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2016-07-21 | — | — | US | disclosed |
| US-20160207883-A1 | NOVEL AROMATIC COMPOUND AND USE THEREOF | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2016-07-21 | — | — | US | disclosed |
| EP-3040329-A1 | NOVEL AROMATIC COMPOUND AND USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2016-07-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207883-A1 | NOVEL AROMATIC COMPOUND AND USE THEREOF | SOST, BMP2, ALPI | SLC6A2 344/4885SLC6A4 820/4885MAOB 595/4885 |
| US-20210100783-A1 | NOVEL CYCLIN-DEPENDENT KINASE 8 AND/OR 19 INHIBITOR | CCNI, CDK9, CDK8 | SLC6A2 4668/4885SLC6A4 4646/4885MAOB 3903/4885 |
| US-11013728-B2 | Cyclin-dependent kinase 8 and/or 19 inhibitor | CCNI, CDK9, CDKN1A | SLC6A2 4701/4885SLC6A4 4670/4885MAOB 3969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.