Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2188442 | 0.87 | NPC1 (0.47) | LMNAALDH1A1TSHRGAAALOX15 | |
| SCHEMBL27679765 | 0.84 | LMNA (0.44) | LMNAMAPTKDM4ENPSR1ALDH1A1 | |
| SCHEMBL27679766 | 0.82 | LMNA (0.43) | LMNAMAPTKDM4ENPSR1ALDH1A1 | |
| SCHEMBL27679675 | 0.81 | LMNA (0.50) | LMNAMAPTALDH1A1TSHRALOX15 | |
| SCHEMBL2186625 | 0.80 | MAPT (0.56) | LMNAMAPTNPSR1ALDH1A1TSHR | |
| SCHEMBL2188486 | 0.80 | MAPK1 (0.40) | LMNAMAPTALDH1A1TSHRGAA | |
| SCHEMBL2187333 | 0.80 | MAPT (0.51) | LMNAMAPTALDH1A1TSHRALOX15 | |
| SCHEMBL5063079 | 0.79 | ALDH1A1 (0.42) | MAPTALDH1A1TSHRMAPK1RAB9A | |
| SCHEMBL2185718 | 0.79 | LMNA (0.40) | LMNAALDH1A1TSHRGAAALOX15 | |
| SCHEMBL2186974 | 0.78 | CACNA2D1 (0.48) | LMNAMAPTKDM4ENPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |