Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ME2 | P23368 | 1/20 | 0.37 |
| ▸ | ME1 | P48163 | 1/20 | 0.37 |
| ▸ | ME3 | Q16798 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2188442 | 0.90 | NPC1 (0.47) | MAPK1LMNAALOX15TSHRGAA | |
| SCHEMBL2188684 | 0.84 | KMT2A (0.39) | MAPK1LMNAALOX15TSHRGAA | |
| SCHEMBL27679675 | 0.80 | LMNA (0.50) | MAPK1LMNAALOX15TSHRPOLB | |
| SCHEMBL2186946 | 0.80 | LMNA (0.46) | MAPK1LMNAALOX15TSHRGAA | |
| SCHEMBL2187044 | 0.78 | TRPC6 (0.40) | MAPK1LMNAGAAATMNPC1 | |
| SCHEMBL2186625 | 0.78 | MAPT (0.56) | MAPK1LMNAALOX15TSHRATM | |
| SCHEMBL2187707 | 0.77 | MLNR (0.41) | MAPK1LMNAALOX15TSHRGAA | |
| SCHEMBL2187555 | 0.76 | MEN1 (0.50) | LMNAATMPOLBME2ME1 | |
| SCHEMBL2186813 | 0.76 | SCD5 (0.43) | MAPK1LMNAALOX15TSHRPOLB | |
| SCHEMBL2186581 | 0.76 | KMT2A (0.52) | MAPK1LMNATSHRGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |