Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.43 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2188486 | 0.90 | MAPK1 (0.40) | NPC1RAB9AKMT2ALMNAALOX15 | |
| SCHEMBL2186946 | 0.87 | LMNA (0.46) | NPC1RAB9ALMNAALOX15TSHR | |
| SCHEMBL2186625 | 0.83 | MAPT (0.56) | RAB9AMEN1KMT2ALMNAALOX15 | |
| SCHEMBL27679675 | 0.82 | LMNA (0.50) | MEN1KMT2ALMNAALOX15TSHR | |
| SCHEMBL2185718 | 0.81 | LMNA (0.40) | RAB9ALMNAALOX15TSHRMAPK1 | |
| SCHEMBL2188722 | 0.81 | KDM4E (0.57) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL2186974 | 0.81 | CACNA2D1 (0.48) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL2186813 | 0.79 | SCD5 (0.43) | LMNAALOX15TSHRMAPK1TRPC3 | |
| SCHEMBL2188684 | 0.79 | KMT2A (0.39) | KMT2ALMNAALOX15TSHRMAPK1 | |
| SCHEMBL2187333 | 0.79 | MAPT (0.51) | KMT2ALMNAALOX15TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |