Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS1 | Q86VZ5 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5668410 | 0.85 | LTA4H (0.48) | SGMS1CACNA1GCACNA1HCACNA1IMAPT | |
| SCHEMBL5670058 | 0.84 | TRPV1 (0.45) | SGMS1CACNA1GCACNA1HCACNA1IMAPT | |
| SCHEMBL2171605 | 0.84 | TRPV1 (0.58) | SGMS1TP53CACNA1GCACNA1HCACNA1I | |
| SCHEMBL5667686 | 0.83 | CACNA1G (0.46) | CACNA1GCACNA1HCACNA1IMAPTTRPV1 | |
| SCHEMBL4387708 | 0.80 | TRPV1 (0.44) | TP53MAPTTRPV1CA1CA2 | |
| SCHEMBL2171492 | 0.78 | TRPV1 (0.56) | CACNA1GCACNA1HCACNA1ITRPV1KMT2A | |
| SCHEMBL5669931 | 0.75 | ALDH1A1 (0.52) | CACNA1GCACNA1HCACNA1IMAPTKMT2A | |
| SCHEMBL4392401 | 0.74 | CACNA1G (0.51) | CACNA1GCACNA1HCACNA1ITRPV1EPHX2 | |
| SCHEMBL2172285 | 0.73 | CACNA1G (0.45) | CACNA1GCACNA1HCACNA1IKMT2ARAB9A | |
| SCHEMBL12407146 | 0.73 | CACNA1G (0.48) | CACNA1GCACNA1HCACNA1ITRPV1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973061-B2 | Anaplastic lymphoma kinase modulators and methods of use | EXELIXIS, INC. (US) | 2011-07-05 | — | — | US | claimed |