SCHEMBL5667686

SCHEMBL5667686

Cc1ccc(CCNC(=O)c2coc(CNC(=O)COc3ccc(OC(F)(F)F)cc3)n2)cc1C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1G O43497 1/20 0.46
CACNA1H O95180 1/20 0.46
CACNA1I Q9P0X4 1/20 0.46
RXFP1 Q9HBX9 2/20 0.42
TRPV1 Q8NER1 2/20 0.42
HPGD P15428 2/20 0.41
ALDH1A1 P00352 1/20 0.41
MAPT P10636 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
ADRB2 P07550 1/20 0.40
KLKB1 P03952 1/20 0.40
SCN10A Q9Y5Y9 1/20 0.40
LTA4H P09960 1/20 0.39
EPHX2 P34913 1/20 0.39
LMNA P02545 1/20 0.39
PKM P14618 1/20 0.39
MCHR1 Q99705 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5668410 0.87 LTA4H (0.48) CACNA1GCACNA1HCACNA1ITRPV1HPGD
SCHEMBL5670058 0.86 TRPV1 (0.45) CACNA1GCACNA1HCACNA1ITRPV1MAPT
SCHEMBL2171605 0.86 TRPV1 (0.58) CACNA1GCACNA1HCACNA1ITRPV1ALDH1A1
SCHEMBL2187253 0.83 SGMS1 (0.42) CACNA1GCACNA1HCACNA1ITRPV1MAPT
SCHEMBL2171492 0.82 TRPV1 (0.56) CACNA1GCACNA1HCACNA1ITRPV1MEN1
SCHEMBL5669931 0.81 ALDH1A1 (0.52) CACNA1GCACNA1HCACNA1IALDH1A1MAPT
SCHEMBL4392401 0.80 CACNA1G (0.51) CACNA1GCACNA1HCACNA1ITRPV1HPGD
SCHEMBL2172285 0.79 CACNA1G (0.45) CACNA1GCACNA1HCACNA1IHPGDALDH1A1
SCHEMBL12407140 0.79 CACNA1G (0.53) CACNA1GCACNA1HCACNA1IALDH1A1KMT2A
SCHEMBL12407146 0.77 CACNA1G (0.48) CACNA1GCACNA1HCACNA1ITRPV1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1730128-A1 ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE Exelixis, Inc. (US) 2006-12-13 EP claimed
WO-2005097765-A1 ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE EXELIXIS, INC. (US) 2005-10-20 WO claimed