Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.56 |
| ▸ | TET3 | O43151 | 2/20 | 0.47 |
| ▸ | FBXL19 | Q6PCT2 | 2/20 | 0.47 |
| ▸ | CXXC5 | Q7LFL8 | 2/20 | 0.47 |
| ▸ | TET1 | Q8NFU7 | 2/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.47 |
| ▸ | CXXC4 | Q9H2H0 | 2/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10351011 | 0.93 | KMT2A (0.59) | KMT2AMEN1TSHRAKR1C1TET3 | |
| SCHEMBL21874228 | 0.88 | KMT2A (0.54) | KMT2AMEN1TSHRAKR1C1TET3 | |
| SCHEMBL4812653 | 0.83 | KMT2A (0.76) | KMT2AMEN1TSHRAKR1C1TET3 | |
| SCHEMBL21964342 | 0.81 | HSD11B1 (0.59) | KMT2AMEN1TSHRCYP3A4CYP2C19 | |
| SCHEMBL11232365 | 0.81 | KMT2A (0.73) | KMT2AMEN1TSHRAKR1C1TET3 | |
| SCHEMBL10319694 | 0.81 | KMT2A (0.64) | KMT2AMEN1TSHRAKR1C1TET3 | |
| SCHEMBL27078205 | 0.80 | MEN1 (0.63) | KMT2AMEN1TSHRAKR1C1CYP2C19 | |
| SCHEMBL21874089 | 0.80 | APOBEC3A (0.46) | KMT2AMEN1TSHRHTTALDH1A1 | |
| SCHEMBL27078208 | 0.79 | KMT2A (0.62) | KMT2AMEN1TSHRAKR1C1TET3 | |
| SCHEMBL21874210 | 0.79 | MEN1 (0.62) | KMT2AMEN1TSHRAKR1C1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11274100-B2 | EP300/CREBBP inhibitor | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-03-15 | — | — | US | disclosed |
| US-20210171520-A1 | EP300/CREBBP INHIBITOR | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-06-10 | — | — | US | disclosed |
| US-20210171520-A1 | EP300/CREBBP INHIBITOR | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-06-10 | — | — | US | disclosed |
| EP-3643703-A1 | EP300/CREBBP INHIBITOR | Daiichi Sankyo Co., Ltd. (JP) | 2020-04-29 | — | — | EP | disclosed |
| EP-3643703-A1 | EP300/CREBBP INHIBITOR | Daiichi Sankyo Co., Ltd. (JP) | 2020-04-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11274100-B2 | EP300/CREBBP inhibitor | EP300, CREBBP, CREB1 | KMT2A 124/4885MEN1 3511/4885TSHR 2614/4885 |
| US-20210171520-A1 | EP300/CREBBP INHIBITOR | EP300, CREBBP, CREB1 | KMT2A 124/4885MEN1 3511/4885TSHR 2614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.