Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186266 | 0.94 | HSD11B1 (0.43) | HSD11B1MGLLGAAPOLBCACNA1B | |
| SCHEMBL2188775 | 0.88 | MGLL (0.53) | HSD11B1MGLLCACNA1BHCRTR1HCRTR2 | |
| SCHEMBL13419197 | 0.84 | MTTP (0.49) | GAAPOLBMAPTL3MBTL1HCRTR1 | |
| SCHEMBL28768418 | 0.84 | HSD11B1 (0.53) | HSD11B1MGLLPOLBCACNA1BHCRTR1 | |
| SCHEMBL4294205 | 0.81 | HSD11B1 (0.52) | HSD11B1MGLLPOLBCACNA1BHCRTR1 | |
| SCHEMBL2187423 | 0.76 | MGLL (0.41) | HSD11B1MGLLCACNA1BHCRTR1HCRTR2 | |
| SCHEMBL3049583 | 0.76 | HSD11B1 (0.52) | HSD11B1MGLLPOLBCACNA1BHCRTR1 | |
| SCHEMBL2187198 | 0.76 | HSD11B1 (0.44) | HSD11B1MGLLCACNA1BHCRTR1HCRTR2 | |
| SCHEMBL2185794 | 0.76 | HSD11B1 (0.39) | HSD11B1MGLLCACNA1BHCRTR1HCRTR2 | |
| SCHEMBL5265670 | 0.75 | HSD11B1 (0.43) | HSD11B1MGLLHCRTR1HCRTR2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |