Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | SPR | P35270 | 2/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.44 |
| ▸ | UBE2M | P61081 | 4/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28768418 | 0.91 | HSD11B1 (0.53) | HSD11B1MGLLHCRTR1HCRTR2CACNA1B | |
| SCHEMBL3049583 | 0.84 | HSD11B1 (0.52) | HSD11B1MGLLHCRTR1HCRTR2CACNA1B | |
| SCHEMBL2187636 | 0.84 | HSD11B1 (0.45) | HSD11B1MGLLCYP2C9SCN9ASPR | |
| SCHEMBL2187198 | 0.82 | HSD11B1 (0.44) | HSD11B1MGLLHCRTR1HCRTR2CACNA1B | |
| SCHEMBL2187368 | 0.82 | MGLL (0.43) | HSD11B1MGLLSPRHCRTR1HCRTR2 | |
| SCHEMBL2188775 | 0.82 | MGLL (0.53) | HSD11B1MGLLSCN9AHCRTR1HCRTR2 | |
| SCHEMBL2188215 | 0.82 | HCRTR1 (0.45) | HSD11B1MGLLCYP2C9HCRTR1HCRTR2 | |
| SCHEMBL2186848 | 0.82 | TSHR (0.52) | HSD11B1MGLLHCRTR1HCRTR2CACNA1B | |
| SCHEMBL2187340 | 0.81 | LMNA (0.57) | HSD11B1CYP2C9CACNA1BLMNAPOLB | |
| SCHEMBL2188543 | 0.81 | ALDH1A1 (0.52) | HSD11B1MGLLHCRTR1HCRTR2CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090304632-A1 | HETEROCYCLIC NF-kB INHIBITORS | 4SC AG (DE) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090304632-A1 | HETEROCYCLIC NF-kB INHIBITORS | NFKBIA, NFKB2, IKBKB | HSD11B1 699/4885MGLL 4659/4885CYP2C9 4002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.