Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 2/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187477 | 0.88 | HSD11B1 (0.43) | MGLLHSD11B1CACNA1BHCRTR1HCRTR2 | |
| SCHEMBL2186266 | 0.88 | HSD11B1 (0.43) | MGLLHSD11B1CACNA1BHCRTR1HCRTR2 | |
| SCHEMBL28768418 | 0.83 | HSD11B1 (0.53) | MGLLHSD11B1CACNA1BHCRTR1HCRTR2 | |
| SCHEMBL4294205 | 0.82 | HSD11B1 (0.52) | MGLLHSD11B1SCN9ACACNA1BHCRTR1 | |
| SCHEMBL2186848 | 0.79 | TSHR (0.52) | MGLLHSD11B1CACNA1BHCRTR1HCRTR2 | |
| SCHEMBL3049583 | 0.77 | HSD11B1 (0.52) | MGLLHSD11B1CACNA1BHCRTR1HCRTR2 | |
| SCHEMBL2187423 | 0.76 | MGLL (0.41) | MGLLHSD11B1CACNA1BHCRTR1HCRTR2 | |
| SCHEMBL2187426 | 0.75 | HRH1 (0.46) | HSD11B1KCNH2 | |
| SCHEMBL2185794 | 0.75 | HSD11B1 (0.39) | MGLLHSD11B1CACNA1BHCRTR1HCRTR2 | |
| SCHEMBL2187198 | 0.75 | HSD11B1 (0.44) | MGLLHSD11B1CACNA1BHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |