Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ACKR3 | P25106 | 6/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20640361 | 0.83 | ALDH1A1 (0.44) | KDM4EALDH1A1ACKR3SIGMAR1HPGD | |
| SCHEMBL20640293 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1TSHRHSD17B10GABRA5 | |
| SCHEMBL28399201 | 0.78 | OPRM1 (0.46) | ALDH1A1ACKR3SIGMAR1HPGDKCNJ6 | |
| SCHEMBL19820647 | 0.76 | HSD17B10 (0.47) | KDM4EALDH1A1HSD17B10GABRA5GABRB2 | |
| Hydrochloric Acid SCHEMBL20640317 | 0.75 | HSD17B10 (0.46) | KDM4EALDH1A1HSD17B10GABRA5GABRB2 | |
| Hydrochloric Acid SCHEMBL19814023 | 0.75 | HSD17B10 (0.46) | KDM4EALDH1A1HSD17B10GABRA5GABRB2 | |
| SCHEMBL5240163 | 0.74 | GABRA5 (0.50) | KDM4EALDH1A1TSHRHSD17B10GABRA5 | |
| SCHEMBL20640319 | 0.73 | LMNA (0.41) | KDM4EALDH1A1TSHRHSD17B10GABRA5 | |
| SCHEMBL20640322 | 0.73 | LMNA (0.41) | KDM4EALDH1A1TSHRHSD17B10GABRA5 | |
| SCHEMBL20648977 | 0.72 | F2 (0.46) | KDM4EALDH1A1HSD17B10GABRA5GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110997678-B | Pyrazoloquinazoline derivatives as choline kinase inhibitors | 内尔维亚诺医疗科学公司 | 2023-02-21 | — | — | CN | disclosed |
| US-11117901-B2 | Substituted pyrazolo[4,3-h]quinazolines as choline kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2021-09-14 | — | — | US | disclosed |
| US-20200131188-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES AS CHOLINE KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2020-04-30 | — | — | US | disclosed |
| CN-110997678-A | Pyrazoloquinazoline derivatives as choline kinase inhibitors | 内尔维亚诺医疗科学公司 | 2020-04-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200131188-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES AS CHOLINE KINASE INHIBITORS | CHKA, CHKB, NADK | KDM4E 924/4885ALDH1A1 2929/4885TSHR 4297/4885 |
| US-11117901-B2 | Substituted pyrazolo[4,3-h]quinazolines as choline kinase inhibitors | CHKA, CHKB, NADK | KDM4E 876/4885ALDH1A1 2234/4885TSHR 4044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.