Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187668 | 0.85 | KMT2A (0.48) | GAATDP1L3MBTL1MAPK1NPC1 | |
| SCHEMBL2187578 | 0.82 | TDP1 (0.46) | GAAMAPTGFERTDP1L3MBTL1 | |
| SCHEMBL2187370 | 0.77 | SCD (0.48) | GAANPC1RAB9APKMMEN1 | |
| SCHEMBL8442374 | 0.74 | NPC1 (0.52) | MAPTALDH1A1HSD17B10NPC1RAB9A | |
| Bromide SCHEMBL6705318 | 0.73 | NPC1 (0.51) | MAPTALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL2187514 | 0.71 | SMN1; SMN2 (0.46) | TDP1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6705418 | 0.71 | ALDH1A1 (0.55) | MAPTALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL2186525 | 0.70 | NFKB1 (0.45) | TDP1MAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2187048 | 0.70 | NPC1 (0.63) | MAPTHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2186689 | 0.70 | NPC1 (0.52) | MAPTHSD17B10NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |