Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 8/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169808 | 0.90 | SCN9A (0.48) | SCN9AALDH1A1GPR34 | |
| SCHEMBL2171621 | 0.90 | QRFPR (0.50) | SCN9AALDH1A1GPR34 | |
| SCHEMBL2171851 | 0.90 | KMT2A (0.53) | SCN9AHPGDKMT2AALDH1A1 | |
| SCHEMBL2173714 | 0.90 | SCN9A (0.45) | SCN9AHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL2170108 | 0.89 | LMNA (0.52) | SCN9AMEN1KMT2AALDH1A1POLB | |
| SCHEMBL2169958 | 0.89 | SCN9A (0.47) | SCN9AMEN1KMT2AALDH1A1 | |
| SCHEMBL2170398 | 0.89 | ALDH1A1 (0.51) | SCN9AALDH1A1KDM4ETSHR | |
| SCHEMBL2350905 | 0.87 | HPGD (0.48) | SCN9AHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL2170146 | 0.87 | SCN9A (0.48) | SCN9AMEN1KMT2AALDH1A1 | |
| SCHEMBL2170811 | 0.87 | MAPT (0.54) | SCN9AMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |