Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
| ▸ | MGLL | Q99685 | 7/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | CCKAR | P32238 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187895 | 0.90 | CCKAR (0.41) | HTR2BMGLLHSD11B1RBP4CCKAR | |
| SCHEMBL2187003 | 0.84 | CSNK1E (0.54) | HTR2BMGLLHSD11B1TP53RBP4 | |
| SCHEMBL28768418 | 0.81 | HSD11B1 (0.53) | MGLLHSD11B1TP53MAPK8MAPK10 | |
| SCHEMBL2186848 | 0.81 | TSHR (0.52) | MGLLHSD11B1MAPTLMNA | |
| SCHEMBL2188215 | 0.81 | HCRTR1 (0.45) | MGLLHSD11B1LMNAUBE2MDCUN1D1 | |
| SCHEMBL2187577 | 0.81 | CSNK1E (0.47) | HTR2BMGLLHSD11B1RBP4 | |
| SCHEMBL4294205 | 0.81 | HSD11B1 (0.52) | MGLLHSD11B1TP53LMNAUBE2M | |
| SCHEMBL2187340 | 0.80 | LMNA (0.57) | HSD11B1MAPTLMNA | |
| SCHEMBL5265670 | 0.80 | HSD11B1 (0.43) | MGLLHSD11B1MAPK8MAPK10UBE2M | |
| SCHEMBL2188543 | 0.80 | ALDH1A1 (0.52) | MGLLHSD11B1MAPTLMNAUBE2M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |