Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | XDH | P47989 | 5/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171221 | 0.90 | SYK (0.44) | SYKXDHPPARAS1PR3NR1I2 | |
| SCHEMBL2173127 | 0.85 | XDH (0.43) | SYKXDHWNT3AS1PR3P2RX3 | |
| SCHEMBL2188021 | 0.84 | XDH (0.43) | SYKXDHPPARAWNT3AS1PR3 | |
| SCHEMBL2170747 | 0.80 | S1PR3 (0.40) | SYKWNT3AS1PR3NR1I2CYP2C9 | |
| SCHEMBL3475703 | 0.80 | LDHA (0.42) | XDHWNT3A | |
| SCHEMBL3474932 | 0.78 | XDH (0.40) | XDHWNT3AP2RX3P2RX2 | |
| SCHEMBL2171259 | 0.77 | P2RX3 (0.55) | NR1I2CYP2C9P2RX3P2RX2 | |
| SCHEMBL7948269 | 0.75 | DHODH (0.44) | PPARANR1I2CYP2C9P2RX3P2RX2 | |
| SCHEMBL3476174 | 0.72 | GRM5 (0.43) | MRGPRX4 | |
| SCHEMBL3475350 | 0.72 | NR1I2 (0.42) | XDHNR1I2P2RX3P2RX2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346825-A2 | MODULATORS OF P2X3 RECEPTOR ACTIVITY | Evotec AG (DE) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010033168-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2010-03-25 | — | — | WO | disclosed |