Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 5/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.47 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29436908 | 1.00 | ATF4 (0.50) | ATF4TAS1R3TAS1R1BCAT1HTR1A | |
| SCHEMBL29436915 | 0.88 | ATF4 (0.59) | ATF4TAS1R3TAS1R1BCAT1CHRNB2 | |
| SCHEMBL21882067 | 0.88 | ATF4 (0.59) | ATF4TAS1R3TAS1R1BCAT1CHRNB2 | |
| SCHEMBL21819377 | 0.87 | ATF4 (0.54) | ATF4TAS1R3TAS1R1BCAT1ACHE | |
| SCHEMBL21882039 | 0.82 | ATF4 (0.49) | ATF4TAS1R3TAS1R1BCAT1CHRNB2 | |
| SCHEMBL28584278 | 0.79 | TAS1R3 (0.51) | ATF4TAS1R3TAS1R1BCAT1CHRNB2 | |
| Trifluoroacetic Acid SCHEMBL21819317 | 0.79 | BCAT1 (0.48) | ATF4TAS1R3TAS1R1BCAT1CHRNB2 | |
| SCHEMBL21050155 | 0.75 | RAB9A (0.51) | ATF4TAS1R3TAS1R1BCAT1CHRNB2 | |
| SCHEMBL21050159 | 0.75 | RAB9A (0.51) | ATF4TAS1R3TAS1R1BCAT1CHRNB2 | |
| SCHEMBL29356799 | 0.75 | RAB9A (0.51) | ATF4TAS1R3TAS1R1BCAT1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11166942-B2 | Inhibitors of integrated stress response pathway | Praxis Biotech LLC (US) | 2021-11-09 | — | — | US | disclosed |
| CN-112912082-A | Integrated stress pathway inhibitors | 普拉西斯生物技术有限责任公司 | 2021-06-04 | — | — | CN | disclosed |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2020-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11166942-B2 | Inhibitors of integrated stress response pathway | ATF4, DDIT3, ATF1 | ATF4 1/4885TAS1R3 3579/4885TAS1R1 3356/4885 |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | ATF4 1/4885TAS1R3 3579/4885TAS1R1 3356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.