Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | PNP | P00491 | 2/20 | 0.43 |
| ▸ | PARN | O95453 | 1/20 | 0.43 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7111111 | 0.86 | PNP (0.56) | SMN1; SMN2ALDH1A1KMT2AHPGDCYP11B1 | |
| Hydrochloric Acid SCHEMBL7114730 | 0.85 | PNP (0.55) | SMN1; SMN2ALDH1A1KMT2AHPGDCYP11B1 | |
| SCHEMBL7973932 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1KMT2AHPGDCYP11B1 | |
| SCHEMBL7991402 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1KMT2AHPGDCYP11B1 | |
| SCHEMBL7975265 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1KMT2AHPGDPNP | |
| SCHEMBL9905498 | 0.81 | HPGD (0.47) | SMN1; SMN2ALDH1A1KMT2AHPGDCYP11B1 | |
| SCHEMBL7984453 | 0.81 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1KMT2AHPGDPNP | |
| SCHEMBL7984716 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1KMT2AHPGDCYP11B1 | |
| SCHEMBL7986518 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1KMT2AHPGDCYP11B1 | |
| SCHEMBL3426471 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1KMT2AHPGDPNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12157739-B2 | Hypoxanthine compounds | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2024-12-03 | — | — | US | disclosed |
| CN-112673008-B | Hypoxanthine compounds | 橘生药品工业株式会社 | 2023-07-18 | — | — | CN | disclosed |
| US-20210214357-A1 | HYPOXANTHINE COMPOUNDS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2021-07-15 | — | — | US | disclosed |
| CN-112673008-A | Hypoxanthine compound | 橘生药品工业株式会社 | 2021-04-16 | — | — | CN | disclosed |
| WO-2020054825-A1 | HYPOXANTHINE COMPOUND | キッセイ薬品工業株式会社 | 2020-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12157739-B2 | Hypoxanthine compounds | HPRT1, APRT, IMPDH1 | SMN1; SMN2 1846/4885ALDH1A1 108/4885KMT2A 297/4885 |
| US-20210214357-A1 | HYPOXANTHINE COMPOUNDS | HPRT1, DHPS, PAH | SMN1; SMN2 3418/4885ALDH1A1 174/4885KMT2A 168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.