Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 3/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | USP7 | Q93009 | 2/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19880434 | 0.81 | ALOX5 (0.42) | — | |
| SCHEMBL23492884 | 0.77 | ESR1 (0.33) | ESR1ADRB2ADRB1 | |
| SCHEMBL19780236 | 0.76 | ESR1 (0.40) | TRPV4ESR1ESR2CYP11B1CYP11B2 | |
| SCHEMBL26690821 | 0.74 | TRPV4 (0.45) | TRPV4ESR1ESR2KHKAR | |
| SCHEMBL19779849 | 0.73 | ADRB2 (0.33) | TRPV4ESR1ESR2CYP11B1CYP11B2 | |
| SCHEMBL19021947 | 0.72 | TRPV4 (0.39) | TRPV4ESR1ESR2CYP11B1CYP11B2 | |
| SCHEMBL18397212 | 0.72 | ESR1 (0.40) | TRPV4ESR1ESR2CYP11B1CYP11B2 | |
| SCHEMBL21883580 | 0.72 | HPGD (0.41) | ESR1ESR2ARTTR | |
| SCHEMBL19780128 | 0.72 | TRPV4 (0.48) | TRPV4ESR1ESR2KHKAR | |
| SCHEMBL13804127 | 0.72 | TRPV4 (0.38) | TRPV4CYP11B1CYP11B2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597377-B2 | Somatostatin modulators and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2020-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10597377-B2 | Somatostatin modulators and uses thereof | SSTR5, SSTR2, SSTR4 | TRPV4 1233/4885ESR1 1952/4885ESR2 635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.