Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1197147 | 0.84 | PTGS2 (0.36) | KIF11PTGS2PTGS1KDM4EPOLB | |
| SCHEMBL5052857 | 0.71 | PTGS2 (0.74) | KIF11PTGS2PTGS1RORCALDH1A1 | |
| SCHEMBL4728987 | 0.70 | GAA (0.36) | PTGS2PTGS1ALDH1A1CYP3A4 | |
| SCHEMBL3066974 | 0.70 | ENPP2 (0.43) | PTGS2 | |
| SCHEMBL509338 | 0.70 | CYP1A2 (0.42) | KIF11PTGS2POLBMEN1KMT2A | |
| SCHEMBL15063601 | 0.69 | CYP1A2 (0.46) | KIF11POLBCYP1A2RAB9AMAPK1 | |
| SCHEMBL18230264 | 0.68 | PLCG1 (0.33) | PTGS2 | |
| SCHEMBL18230176 | 0.68 | L3MBTL1 (0.39) | L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL9118988 | 0.68 | PTGS2 (0.45) | KIF11PTGS2PTGS1KDM4EPOLB | |
| SCHEMBL18230380 | 0.67 | ADH5 (0.49) | ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2341775-A1 | INHIBITORS OF JANUS KINASES | Merck & Co., Inc. (US) | 2011-07-13 | — | — | EP | disclosed |