Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 4/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 8/20 | 0.43 |
| ▸ | AXL | P30530 | 4/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | STK25 | O00506 | 1/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | MUSK | O15146 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21885580 | 0.92 | HSD17B10 (0.45) | KDRPDGFRBHSD17B10SRCEGFR | |
| SCHEMBL21884832 | 0.83 | KDR (0.45) | KDRPDGFRBSRCTGFBR1MET | |
| SCHEMBL21884833 | 0.83 | KDR (0.56) | KDRPDGFRBHSD17B10SRCTGFBR1 | |
| SCHEMBL21884863 | 0.81 | KDR (0.62) | KDRPDGFRBSRCTGFBR1EGFR | |
| SCHEMBL21884876 | 0.81 | KDR (0.62) | KDRPDGFRBSRCTGFBR1EGFR | |
| SCHEMBL21884882 | 0.80 | KDR (0.57) | KDRPDGFRBSRCTGFBR1EGFR | |
| SCHEMBL21884881 | 0.80 | KDR (0.57) | KDRPDGFRBSRCTGFBR1EGFR | |
| SCHEMBL3903233 | 0.79 | SRC (0.58) | KDRPDGFRBHSD17B10SRCTGFBR1 | |
| SCHEMBL30365130 | 0.79 | KDR (0.57) | KDRPDGFRBSRCTGFBR1EGFR | |
| SCHEMBL21884877 | 0.79 | KDR (0.57) | KDRPDGFRBSRCTGFBR1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020057403-A1 | INDOLE DERIVATIVE AND MEDICAL APPLICATION THEREOF | 北京越之康泰生物医药科技有限公司 | 2020-03-26 | — | — | WO | disclosed |