Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 4/20 | 0.38 |
| ▸ | NOS2 | P35228 | 4/20 | 0.38 |
| ▸ | NOS1 | P29475 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CBLB | Q13191 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29404447 | 1.00 | NOS3 (0.38) | NOS3NOS2NOS1KDM4EMEN1 | |
| SCHEMBL3756200 | 0.77 | MAPT (0.41) | KDM4EMEN1KMT2A | |
| SCHEMBL21887849 | 0.75 | ELOVL1 (0.38) | NOS3NOS2NOS1KDM4EMEN1 | |
| SCHEMBL29404627 | 0.74 | NOS3 (0.37) | NOS3NOS2NOS1KDM4EMEN1 | |
| SCHEMBL26029289 | 0.73 | ALDH1A1 (0.41) | KDM4EMEN1KMT2A | |
| SCHEMBL15980615 | 0.73 | SMN1; SMN2 (0.44) | KDM4EMEN1KMT2A | |
| SCHEMBL21849574 | 0.72 | NOTUM (0.44) | MEN1KMT2A | |
| SCHEMBL13160181 | 0.71 | NOTUM (0.51) | MEN1KMT2A | |
| SCHEMBL13183613 | 0.71 | KMT2A (0.41) | MEN1KMT2A | |
| SCHEMBL22185934 | 0.71 | RXRA (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020061112-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2020-03-26 | — | — | WO | disclosed |