Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 15/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 14/20 | 0.34 |
| ▸ | RXRA | P19793 | 7/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21887872 | 0.85 | NR1H2 (0.39) | NR1H2NR1H3RXRACFTRJAK2 | |
| SCHEMBL21887769 | 0.82 | NR1H2 (0.59) | NR1H2NR1H3RXRAPTGS2 | |
| SCHEMBL21888601 | 0.80 | NR1H2 (0.42) | NR1H2NR1H3RXRAPTGS2 | |
| SCHEMBL16553546 | 0.76 | NR1H2 (0.67) | NR1H2NR1H3RXRAPTGS2 | |
| SCHEMBL21887871 | 0.68 | NR1H2 (0.43) | NR1H2NR1H3RXRAJAK2JAK3 | |
| SCHEMBL25880815 | 0.67 | NR1H2 (0.55) | NR1H2 | |
| SCHEMBL21888599 | 0.65 | NR1H2 (0.44) | NR1H2NR1H3RXRAJAK2 | |
| SCHEMBL3472767 | 0.61 | NR1H2 (0.45) | NR1H2NR1H3RXRA | |
| SCHEMBL21887741 | 0.61 | NR1H2 (0.47) | NR1H2JAK2JAK1JAK3 | |
| SCHEMBL21887739 | 0.60 | NR1H2 (0.53) | NR1H2NR1H3RXRAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3626712-A2 | LIVER X RECEPTOR (LXR) MODULATORS | Ellora Therapeutics, Inc. (US) | 2020-03-25 | — | — | EP | disclosed |