Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 4/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.45 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 3/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187003 | 0.85 | CSNK1E (0.54) | CSNK1ECSNK1DCSNK1G3MGLLHSD11B1 | |
| SCHEMBL2187132 | 0.84 | CSNK1E (0.54) | CSNK1ECSNK1DCSNK1G3MGLLHSD11B1 | |
| SCHEMBL2187760 | 0.83 | MGLL (0.42) | CSNK1ECSNK1DCSNK1G3MGLLHSD11B1 | |
| SCHEMBL2187368 | 0.82 | MGLL (0.43) | CSNK1ECSNK1DCSNK1G3MGLLHSD11B1 | |
| SCHEMBL2187423 | 0.81 | MGLL (0.41) | CSNK1ECSNK1DCSNK1G3MGLLHSD11B1 | |
| SCHEMBL4294205 | 0.80 | HSD11B1 (0.52) | MGLLHSD11B1HCRTR1HCRTR2KDM5A | |
| SCHEMBL28768418 | 0.80 | HSD11B1 (0.53) | MGLLHSD11B1HCRTR1HCRTR2KDM5A | |
| SCHEMBL2187577 | 0.79 | CSNK1E (0.47) | CSNK1ECSNK1DCSNK1G3MGLLHSD11B1 | |
| SCHEMBL2187918 | 0.78 | CSNK1E (0.46) | CSNK1ECSNK1DCSNK1G3MGLLHSD11B1 | |
| SCHEMBL2187583 | 0.77 | CSNK1E (0.43) | CSNK1ECSNK1DCSNK1G3MGLLHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |