Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | ATM | Q13315 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 3/20 | 0.50 |
| ▸ | MMP2 | P08253 | 3/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3203883 | 0.86 | PKM (0.68) | MAPTLMNARAB9ATP53NPC1 | |
| SCHEMBL3203877 | 0.86 | PKM (0.68) | MAPTLMNARAB9ATP53NPC1 | |
| SCHEMBL10895023 | 0.83 | SIRT2 (0.57) | MAPTLMNARAB9ATP53NPC1 | |
| SCHEMBL17680839 | 0.82 | ALDH1A1 (0.56) | MAPTLMNARAB9ATP53NPC1 | |
| SCHEMBL27340748 | 0.80 | MAPT (0.62) | MAPTLMNARAB9ATP53NPC1 | |
| SCHEMBL7188121 | 0.79 | ALDH1A1 (0.53) | MAPTLMNARAB9ATP53NPC1 | |
| SCHEMBL4398128 | 0.79 | NPSR1 (0.55) | MAPTLMNASMN1; SMN2ALDH1A1RECQL | |
| SCHEMBL4665329 | 0.79 | TTR (0.55) | MAPTLMNARAB9ATP53NPC1 | |
| SCHEMBL6952794 | 0.79 | MAPT (0.52) | MAPTLMNARAB9ATP53NPC1 | |
| SCHEMBL4665327 | 0.79 | TTR (0.55) | MAPTLMNARAB9ATP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10624882-B2 | Rho kinase inhibitors | AERIE PHARMACEUTICALS, INC. (US) | 2020-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10624882-B2 | Rho kinase inhibitors | ROCK1, ROCK2, CIT | MAPT 1764/4885LMNA 1385/4885RAB9A 179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.