Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | CA3 | P07451 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL18297764 | 0.98 | CA12 (0.52) | CA12CA1CA2GLACA3 | |
| Tromethamine SCHEMBL1648213 | 0.83 | ESR1 (0.54) | KDM4EPOLBLMNAESR1ESR2 | |
| Phenol SCHEMBL8343917 | 0.82 | KDM4E (0.43) | CA12CA1CA2GLACA3 | |
| Tromethamine SCHEMBL2953454 | 0.81 | LMNA (0.77) | KDM4EPOLBMEN1KMT2ALMNA | |
| Phenol SCHEMBL8029599 | 0.79 | CA12 (0.61) | CA12CA1CA2GLACA3 | |
| Phenol SCHEMBL10790520 | 0.79 | CA12 (0.61) | CA12CA1CA2GLACA3 | |
| Phenol SCHEMBL21174524 | 0.78 | CA12 (0.52) | CA12CA1CA2GLACA3 | |
| Diphenylmethane SCHEMBL20640848 | 0.78 | CALM1 (0.57) | TDP1KDM4EPOLBMEN1KMT2A | |
| Tromethamine SCHEMBL19813203 | 0.78 | TSHR (0.67) | TDP1KDM4EPOLBMEN1KMT2A | |
| Phenol SCHEMBL27344476 | 0.78 | CA12 (0.79) | CA12CA1CA2GLACA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 247 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114277161-A | Method for rapidly obtaining probiotic drug-resistant gene in bactericidal type dairy product based on high-throughput sequencing technology | 上海市质量监督检验技术研究院 | 2022-04-05 | — | — | CN | claimed |
| CN-109438677-A | A kind of composite curing agent, the resin combination comprising the composite curing agent, prepreg and laminate | 陕西生益科技有限公司 | 2019-03-08 | — | — | CN | claimed |
| CN-109306149-A | It is a kind of have halogen without antimony resin combination, using its prepreg, laminate and printed circuit board | 陕西生益科技有限公司 | 2019-02-05 | — | — | CN | claimed |
| CN-109233209-A | It is a kind of have halogen without antimony resin combination, using its prepreg, laminate and printed circuit board | 陕西生益科技有限公司 | 2019-01-18 | — | — | CN | claimed |
| CN-103477274-B | Liquid crystal sealing agent, the manufacture method using its display panels and display panels | MITSUI CHEMICALS, INC. (JP) | 2016-04-13 | — | — | CN | claimed |
| EP-1590392-B1 | EPOXY RESIN CURING COMPOSITIONS AND EPOXY RESIN COMPOSITIONS INCLUDING SAME | HEXION SPECIALTY CHEMICALS RES (BE) | 2010-03-10 | — | — | EP | claimed |
| EP-1592746-A2 | HALOGEN FREE IGNITION RESISTANT THERMOPLASTIC RESIN COMPOSITIONS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2005-11-09 | — | — | EP | claimed |
| EP-1427682-B1 | METHODS AND ULTRA-LOW DENSITY SEALING COMPOSITIONS FOR SEALING PIPE IN WELL BORES | HALLIBURTON ENERGY SERV INC (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004072179-A1 | HALOGEN FREE IGNITION RESISTANT THERMOPLASTIC RESIN COMPOSITIONS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2004-08-26 | — | — | WO | claimed |
| WO-2004072170-A2 | HALOGEN FREE IGNITION RESISTANT THERMOPLASTIC RESIN COMPOSITIONS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2004-08-26 | — | — | WO | claimed |
| US-5032634-A | Containing organotin stabilizer and hindered phenolic antioxidant | AKZO AMERICA INC. (US) | 1991-07-16 | — | — | US | claimed |
| EP-0169865-A1 | EPOXY RESIN COMPOSITION AND PROCESS FOR PREPARING LAMINATES THEREFROM | THE DOW CHEMICAL COMPANY (US) | 1986-02-05 | — | — | EP | claimed |
| WO-1985003515-A1 | EPOXY RESIN COMPOSITION AND PROCESS FOR PREPARING LAMINATES THEREFROM | THE DOW CHEMICAL COMPANY (US) | 1985-08-15 | — | — | WO | claimed |
| EP-0045517-A1 | Process for passivating a cracking catalyst, cracking catalyst composition and use of same | PHILLIPS PETROLEUM COMPANY (US) | 1982-02-10 | — | — | EP | claimed |
| US-3949024-A | POLYMERIC STABILIZERS | STEPAN CHEMICAL COMPANY (US) | 1976-04-06 | — | — | US | claimed |
| US-12617907-B2 | Resin composition, prepreg using same, film provided with resin, metal foil provided with resin, metal-clad laminate, and wiring board | PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD. (JP) | 2026-05-05 | — | — | US | disclosed |
| US-20260047004-A1 | METHOD FOR PRODUCING METAL FOIL-CLAD LAMINATE, RESIN COMPOSITION, RESIN COMPOSITE SHEET, METHOD FOR PRODUCING PRINTED WIRING BOARD, AND METHOD FOR PRODUCING SEMICONDUCTOR DEVICE | MITSUBISHI GAS CHEMICAL CO (JP) | 2026-02-12 | — | — | US | disclosed |
| US-4474917-A | Phenolic phosphite antioxidant for polymers | ETHYL CORPORATION (US) | 1984-10-02 | — | — | US | disclosed |
| US-3949024-A | POLYMERIC STABILIZERS | STEPAN CHEMICAL COMPANY (US) | 1976-04-06 | — | — | US | disclosed |
| US-3949024-A | POLYMERIC STABILIZERS | STEPAN CHEMICAL COMPANY (US) | 1976-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260047004-A1 | METHOD FOR PRODUCING METAL FOIL-CLAD LAMINATE, RESIN COMPOSITION, RESIN COMPOSITE SHEET, METHOD FOR PRODUCING PRINTED WIRING BOARD, AND METHOD FOR PRODUCING SEMICONDUCTOR DEVICE | SEM1, RIOK1, CBLB | CA12 1294/4885CA1 142/4885CA2 1099/4885 |
| US-12617907-B2 | Resin composition, prepreg using same, film provided with resin, metal foil provided with resin, metal-clad laminate, and wiring board | SUZ12, RXRB, RXRG | CA12 1345/4885CA1 732/4885CA2 1568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.