Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TET3 | O43151 | 2/20 | 0.38 |
| ▸ | FBXL19 | Q6PCT2 | 2/20 | 0.38 |
| ▸ | TET1 | Q8NFU7 | 2/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.38 |
| ▸ | CXXC4 | Q9H2H0 | 2/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.38 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | KRAS | P01116 | 11/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21896284 | 0.88 | KRAS (0.40) | BTKNUDT1KMT2AJAK3KRAS | |
| SCHEMBL22994731 | 0.86 | NUDT1 (0.38) | BTKNUDT1JAK3KRAS | |
| SCHEMBL22994733 | 0.84 | JAK3 (0.40) | BTKNUDT1JAK3KRAS | |
| SCHEMBL21895605 | 0.83 | KRAS (0.43) | BTKJAK3KRAS | |
| SCHEMBL22994789 | 0.82 | KRAS (0.44) | NUDT1JAK3KRAS | |
| SCHEMBL21895574 | 0.80 | KRAS (0.39) | BTKJAK3KRAS | |
| SCHEMBL21846309 | 0.79 | KRAS (0.47) | KRAS | |
| SCHEMBL21895629 | 0.79 | KRAS (0.38) | BTKJAK3KRAS | |
| SCHEMBL22088501 | 0.78 | BTK (0.50) | BTKJAK3KRAS | |
| SCHEMBL21912079 | 0.72 | BTK (0.37) | BTKKMT2ATET3FBXL19TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710439-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2023-02-15 | — | — | EP | disclosed |
| EP-3458445-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2021-02-17 | — | — | EP | disclosed |