Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.97 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.74 |
| ▸ | ACHE | P22303 | 4/20 | 0.69 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.69 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.69 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.69 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.69 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.69 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.69 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.66 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.65 |
| ▸ | HTR6 | P50406 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dehydrostobadine SCHEMBL29468212 | 1.00 | L3MBTL1 (0.97) | L3MBTL1SIRT2ACHEGRIN1GRIN2A | |
| Dehydrostobadine SCHEMBL3715610 | 0.98 | L3MBTL1 (1.00) | L3MBTL1SIRT2ACHEGRIN1GRIN2A | |
| Dehydrostobadine SCHEMBL2837548 | 0.98 | L3MBTL1 (1.00) | L3MBTL1SIRT2ACHEGRIN1GRIN2A | |
| SCHEMBL10127681 | 0.91 | L3MBTL1 (0.82) | L3MBTL1SIRT2ACHEGRIN1GRIN2A | |
| Dehydrostobadine SCHEMBL13320178 | 0.90 | L3MBTL1 (0.80) | L3MBTL1SIRT2ACHEGRIN1GRIN2A | |
| SCHEMBL3238110 | 0.89 | L3MBTL1 (0.78) | L3MBTL1SIRT2ACHEGRIN1GRIN2A | |
| SCHEMBL1120507 | 0.88 | L3MBTL1 (0.76) | L3MBTL1SIRT2ACHEGRIN1GRIN2A | |
| SCHEMBL15977201 | 0.88 | L3MBTL1 (0.76) | L3MBTL1SIRT2ACHEGRIN1GRIN2A | |
| SCHEMBL12868029 | 0.86 | L3MBTL1 (0.73) | L3MBTL1SIRT2ACHEGRIN1GRIN2A | |
| SCHEMBL3024458 | 0.84 | L3MBTL1 (0.70) | L3MBTL1SIRT2ACHEGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 228 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303577-A1 | TEMOZOLOMIDE ANALOGS AND METHODS OF USE | ST. JOHN'S CANCER INSTITUTE (US) | 2023-09-28 | — | — | US | claimed |
| EP-2420235-A1 | Methods and combination therapies for treating alzheimer's disease | Medivation Neurology, Inc. (US) | 2012-02-22 | — | — | EP | claimed |
| US-20100152108-A1 | METHODS AND COMBINATION THERAPIES FOR TREATING ALZHEIMER'S DISEASE | MEDIVATION NEUROLOGY, INC. (US) | 2010-06-17 | — | — | US | claimed |
| US-20100152225-A1 | HYDROGENATED PYRIDO [4,3-B] INDOLES SUCH AS DIMEBON FOR TREATING CANINE COGNITIVE DYSFUNCTION SYNDROME | MEDIVATION NEUROLOGY, INC. | 2010-06-17 | — | — | US | claimed |
| US-20100099700-A1 | HYDROGENATED PYRIDO (4,3-B) INDOLES FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS) | MEDIVATION NEUROLOGY, INC. | 2010-04-22 | — | — | US | claimed |
| WO-2009111540-A1 | METHODS FOR PREPARING PYRIDYLETHYL-SUBSTITUTED CARBOLINES | MEDIVATION NEUROLOGY, INC. (US) | 2009-09-11 | — | — | WO | claimed |
| EP-2086538-A2 | COMBINATION THERAPIES FOR TREATING ALZHEIMER'S DISEASE USING I.A. DIMEBON AND DOLEPEZIL | Medivation Neurology, Inc. (US) | 2009-08-12 | — | — | EP | claimed |
| EP-2063892-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS) | Medivation Neurology, Inc. (US) | 2009-06-03 | — | — | EP | claimed |
| WO-2009039420-A9 | METHODS AND COMPOSITIONS FOR TREATING NEURONAL DEATH MEDIATED OCULAR DISEASES | MEDIVATION NEUROLOGY INC (US) | 2009-05-07 | — | — | WO | claimed |
| WO-2009039420-A1 | METHODS AND COMPOSITIONS FOR TREATING NEURONAL DEATH MEDIATED OCULAR DISEASES | MEDIVATION NEUROLOGY, INC. (US) | 2009-03-26 | — | — | WO | claimed |
| WO-2008036410-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS) | MEDIVATION NEUROLOGY, INC. (US) | 2008-03-27 | — | — | WO | claimed |
| US-20070225316-A1 | Methods and compositions for treating schizophrenia | MEDIVATION, INC. | 2007-09-27 | — | — | US | claimed |
| WO-2007087425-A1 | METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA | MEDIVATION NEUROLOGY,INC. (US) | 2007-08-02 | — | — | WO | claimed |
| US-20070179174-A1 | Methods and compositions for slowing aging | MEDIVATION, INC. | 2007-08-02 | — | — | US | claimed |
| US-20070117835-A1 | Methods and compositions for treating Huntington's disease | MEDIVATION NEUROLOGY, INC. | 2007-05-24 | — | — | US | claimed |
| US-20070117834-A1 | Methods and compositions for treating Huntington's disease | MEDIVATION NEUROLOGY, INC. | 2007-05-24 | — | — | US | claimed |
| WO-2007041697-A2 | HYDROGENATED PYRIDO-INDOLE COMPOUNDS FOR THE TREATMENT OF HUNTINGTON ' S DISEASE | MEDIVATION, INC. (GB) | 2007-04-12 | — | — | WO | claimed |
| EP-1692131-A2 | METHODS AND COMPOSITIONS FOR SLOWING AGING | MEDIVATION, INC. (US) | 2006-08-23 | — | — | EP | claimed |
| WO-2005055951-A2 | METHODS AND COMPOSITIONS FOR SLOWING AGING | MEDIVATION, INC. (US) | 2005-06-23 | — | — | WO | claimed |
| EP-0876818-B1 | AGENT FOR TREATING NEURO-DEGENERATIVE DISORDERS | SELENA PHARMACEUTICALS INC (US) | 2002-12-18 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152108-A1 | METHODS AND COMBINATION THERAPIES FOR TREATING ALZHEIMER'S DISEASE | PSEN2, APP, PSEN1 | L3MBTL1 4152/4885SIRT2 78/4885ACHE 12/4885 |
| US-20070225316-A1 | Methods and compositions for treating schizophrenia | SLC6A3, DBH, GRIN3B | L3MBTL1 4439/4885SIRT2 575/4885ACHE 393/4885 |
| US-20070179174-A1 | Methods and compositions for slowing aging | PRDX5, HMOX1, SHMT2 | L3MBTL1 1438/4885SIRT2 54/4885ACHE 398/4885 |
| US-20070117835-A1 | Methods and compositions for treating Huntington's disease | HTT, HYPK, HTR6 | L3MBTL1 4123/4885SIRT2 284/4885ACHE 171/4885 |
| US-20230303577-A1 | TEMOZOLOMIDE ANALOGS AND METHODS OF USE | MGMT, TOP2B, IDH3B | L3MBTL1 2328/4885SIRT2 284/4885ACHE 2967/4885 |
| US-20100152225-A1 | HYDROGENATED PYRIDO [4,3-B] INDOLES SUCH AS DIMEBON FOR TREATING CANINE COGNITIVE DYSFUNCTION SYNDROME | HPD, KYNU, IDO1 | L3MBTL1 3532/4885SIRT2 319/4885ACHE 1153/4885 |
| US-20100099700-A1 | HYDROGENATED PYRIDO (4,3-B) INDOLES FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS) | HTT, NLN, SMN1; SMN2 | L3MBTL1 321/4885SIRT2 286/4885ACHE 164/4885 |
| US-20070117834-A1 | Methods and compositions for treating Huntington's disease | HTT, HYPK, HTR6 | L3MBTL1 4123/4885SIRT2 284/4885ACHE 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.