Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 14/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21900776 | 0.89 | BTK (0.47) | BTKEGFRJAK3JAK1 | |
| SCHEMBL21899550 | 0.84 | BTK (0.44) | BTKEGFRJAK3JAK1 | |
| SCHEMBL24464321 | 0.81 | HPGDS (0.44) | EGFRJAK1 | |
| SCHEMBL19649106 | 0.80 | BTK (0.65) | BTKEGFRJAK3 | |
| SCHEMBL19649304 | 0.80 | BTK (0.65) | BTKEGFRJAK3 | |
| SCHEMBL21900351 | 0.79 | BTK (0.49) | BTKEGFRJAK3JAK1 | |
| SCHEMBL21899548 | 0.79 | BTK (0.49) | BTKEGFRJAK3JAK1 | |
| SCHEMBL14647420 | 0.78 | BTK (0.50) | BTKEGFRJAK3JAK1 | |
| SCHEMBL19649376 | 0.76 | BTK (0.52) | BTKEGFRJAK3 | |
| SCHEMBL19017336 | 0.75 | BTK (0.55) | BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3257855-B1 | METHOD FOR PREPARING IBRUTINIB | SHANGHAI DUDE MEDICAL SCIENCE AND TECH CO LTD (CN) | 2020-04-22 | — | — | EP | disclosed |