Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22243284 | 0.86 | EGFR (0.47) | HPGDSEGFRLMNAHTTPKM | |
| SCHEMBL21899550 | 0.82 | BTK (0.44) | EGFRJAK1 | |
| SCHEMBL21899804 | 0.81 | BTK (0.47) | EGFRJAK1 | |
| SCHEMBL22243292 | 0.80 | BTK (0.45) | HPGDSEGFRLMNAHTTMAP4K4 | |
| SCHEMBL21159561 | 0.77 | HPGDS (0.53) | HPGDSEGFRLMNAHTTPKM | |
| SCHEMBL18518829 | 0.76 | SMN1; SMN2 (0.39) | LMNAHTTHSD17B10MAP4K4JAK2 | |
| SCHEMBL21900351 | 0.76 | BTK (0.49) | EGFRJAK1 | |
| SCHEMBL21899548 | 0.75 | BTK (0.49) | EGFRJAK1 | |
| SCHEMBL14647420 | 0.74 | BTK (0.50) | EGFRMAP4K4ADORA1JAK1 | |
| SCHEMBL24041268 | 0.74 | BTK (0.58) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4104837-A2 | HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | Cancer Research Technology Limited (GB) | 2022-12-21 | — | — | EP | disclosed |
| EP-3442535-B1 | HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | CANCER RESEARCH TECH LTD (GB) | 2022-06-01 | — | — | EP | disclosed |