Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 11/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | FPR1 | P21462 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28376667 | 1.00 | FPR2 (0.41) | FPR2F10F2PRSS1FPR1 | |
| SCHEMBL8302296 | 0.93 | FPR2 (0.40) | FPR2FPR1GAAUSP30NFKB1 | |
| SCHEMBL23168328 | 0.86 | F10 (0.46) | FPR2F10FPR1USP30 | |
| SCHEMBL23168331 | 0.86 | F10 (0.46) | FPR2F10FPR1USP30 | |
| SCHEMBL20581794 | 0.83 | FPR2 (0.42) | FPR2FPR1 | |
| SCHEMBL20581795 | 0.83 | FPR2 (0.42) | FPR2FPR1 | |
| SCHEMBL8299289 | 0.81 | FPR2 (0.40) | FPR2F10F2PRSS1FPR1 | |
| SCHEMBL18963926 | 0.81 | FPR2 (0.48) | FPR2F10F2PRSS1FPR1 | |
| SCHEMBL18963928 | 0.81 | FPR2 (0.48) | FPR2F10F2PRSS1FPR1 | |
| SCHEMBL8300928 | 0.80 | FPR1 (0.39) | FPR2FPR1GAANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114008059-B | Biaryl dialkylphosphine oxide FPR2 agonists | 百时美施贵宝公司 | 2024-03-12 | — | — | CN | disclosed |
| EP-3986903-B1 | BIARYL DIALKYL PHOSPHINE OXIDE FPR2 AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2023-05-10 | — | — | EP | disclosed |
| EP-3986903-B1 | BIARYL DIALKYL PHOSPHINE OXIDE FPR2 AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2023-05-10 | — | — | EP | disclosed |
| CN-110996950-B | Piperidinone formyl peptide 2 receptor agonists and formyl peptide 1 receptor agonists | 百时美施贵宝公司 | 2023-04-04 | — | — | CN | disclosed |
| US-20220298186-A1 | BIARYL DIALKYL PHOSPHINE OXIDE FPR2 AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2022-09-22 | — | — | US | disclosed |
| EP-3986903-A1 | BIARYL DIALKYL PHOSPHINE OXIDE FPR2 AGONISTS | Bristol-Myers Squibb Company (US) | 2022-04-27 | — | — | EP | disclosed |
| CN-114008059-A | Biaryl dialkylphosphine oxide FPR2 agonists | 百时美施贵宝公司 | 2022-02-01 | — | — | CN | disclosed |
| US-11186544-B2 | Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-11-30 | — | — | US | disclosed |
| WO-2020257161-A1 | BIARYL DIALKYL PHOSPHINE OXIDE FPR2 AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-12-24 | — | — | WO | disclosed |
| US-20200123108-A1 | PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2020-04-23 | — | — | US | disclosed |
| CN-110996950-A | Piperidinone formyl peptide 2 receptor agonists and formyl peptide 1 receptor agonists | 百时美施贵宝公司 | 2020-04-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11186544-B2 | Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists | FPR1, FPR2, FPR3 | FPR2 2/4885F10 2461/4885F2 309/4885 |
| US-20200123108-A1 | PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS | FPR1, FPR2, FPR3 | FPR2 2/4885F10 2461/4885F2 309/4885 |
| US-20220298186-A1 | BIARYL DIALKYL PHOSPHINE OXIDE FPR2 AGONISTS | FPR1, FPR2, FPR3 | FPR2 2/4885F10 2537/4885F2 193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.