Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 2/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994793 | 0.77 | ALDH1A1 (0.36) | PIK3CD | |
| SCHEMBL19369915 | 0.77 | PIK3CD (0.31) | PIK3CD | |
| SCHEMBL5448855 | 0.77 | ALDH1A1 (0.36) | PIK3CD | |
| SCHEMBL5448849 | 0.77 | ALDH1A1 (0.36) | PIK3CD | |
| SCHEMBL9333241 | 0.76 | CNR2 (0.33) | PIK3CD | |
| SCHEMBL10635161 | 0.75 | PKM (0.31) | — | |
| SCHEMBL10635153 | 0.75 | DPP4 (0.32) | — | |
| SCHEMBL27692277 | 0.74 | CNR2 (0.31) | — | |
| SCHEMBL23033819 | 0.73 | DGAT1 (0.43) | — | |
| SCHEMBL28009355 | 0.72 | CNR2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172422-A1 | Methods of Making Pharmacokinetically Improved Compounds Comprising Functional Residues or Groups and Pharmaceutical Compositions Comprising Said Compounds | SURFACE LOGIX, INC. (US) | 2011-07-14 | — | — | US | disclosed |
| US-20100093719-A1 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX, INC. (US) | 2010-04-15 | — | — | US | disclosed |
| CN-101287468-A | Methods of making pharmacokinetically improved compounds comprising functional residues or groups and pharmaceutical compositions comprising said compounds | SURFACE LOGIX INC (US) | 2008-10-15 | — | — | CN | disclosed |
| US-20080176844-A1 | Pharmacokinetically Improved Compounds | SURFACE LOGIX, INC. | 2008-07-24 | — | — | US | disclosed |
| CN-101223171-A | Pharmacokinetic improved compounds | SURFACE LOGIX INC (US) | 2008-07-16 | — | — | CN | disclosed |
| EP-1850853-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | Surface Logix, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| EP-1848437-A2 | METHODS OF MAKING PHARMACOKINETICALLY IMPROVED COMPOUNDS COMPRISING FUNCTIONAL RESIDUES OR GROUPS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID COMPOUNDS | Surface Logix, Inc. (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006089276-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX, INC. (US) | 2006-08-24 | — | — | WO | disclosed |
| WO-2006089275-A2 | METHODS OF MAKING PHARMACOKINETICALLY IMPROVED COMPOUNDS COMPRISING FUNCTIONAL RESIDUES OR GROUPS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID COMPOUNDS | SURFACE LOGIX, INC. (US) | 2006-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172422-A1 | Methods of Making Pharmacokinetically Improved Compounds Comprising Functional Residues or Groups and Pharmaceutical Compositions Comprising Said Compounds | ABCG2, CYP3A5, CYP3A43 | PIK3CD 4249/4885NOS1 2805/4885NOS3 2088/4885 |
| US-20100093719-A1 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, SLC7A1, HRH4 | PIK3CD 4744/4885NOS1 647/4885NOS3 621/4885 |
| US-20080176844-A1 | Pharmacokinetically Improved Compounds | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, SLC7A1, HRH4 | PIK3CD 4744/4885NOS1 647/4885NOS3 621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.