Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174904 | 0.93 | HTR7 (0.46) | HTR7ADRA1DHTR2CADRA1AADRA1B | |
| SCHEMBL2174129 | 0.84 | SCN9A (0.51) | JAK2JAK1JAK3ERBB2SCN9A | |
| SCHEMBL2177165 | 0.78 | ALDH1A1 (0.52) | P2RX3GAAKMT2A | |
| SCHEMBL2177484 | 0.77 | EGFR (0.57) | GAAKMT2ASCN9ABRAFKDR | |
| SCHEMBL8287302 | 0.75 | AURKA (0.51) | KMT2ASCN9AKCNH3 | |
| SCHEMBL13977412 | 0.75 | EGFR (0.44) | JAK2GAAACVRL1KDR | |
| SCHEMBL2176931 | 0.72 | SCN9A (0.50) | GAAKMT2ASCN9AKCNH3 | |
| SCHEMBL2174899 | 0.72 | PLK1 (0.46) | HTR7ADRA1DHTR2CADRA1AADRA1B | |
| SCHEMBL2173982 | 0.68 | RAB9A (0.57) | GAAKMT2AKCNH3 | |
| SCHEMBL31580872 | 0.68 | BRAF (0.48) | P2RX3KMT2AERBB2SCN9AACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519501-A2 | SUBSTITUTED PYRIDINES AND PYRIMIDINES FOR THE PRODUCTION OF CARDIOMYOCYTE-LIKE CELLS | Technische Universität Wien (AT) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011079343-A2 | SUBSTITUTED PYRIDINES AND PYRIMIDINES | TECHNISCHE UNIVERSITAET WIEN (AT) | 2011-07-07 | — | — | WO | disclosed |