SCHEMBL2190488

SCHEMBL2190488

Nc1cnc2nc[nH]c2c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.48
PRKCI P41743 1/20 0.48
KDM4E B2RXH2 4/20 0.47
MAPT P10636 3/20 0.47
RAD52 P43351 1/20 0.47
APEX1 P27695 1/20 0.42
RECQL P46063 1/20 0.42
BLM P54132 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
RXFP1 Q9HBX9 1/20 0.39
PI4KA P42356 2/20 0.36
PI4K2B Q8TCG2 2/20 0.36
PI4K2A Q9BTU6 2/20 0.36
PI4KB Q9UBF8 2/20 0.36
LMNA P02545 1/20 0.36
DRD3 P35462 1/20 0.36
XDH P47989 1/20 0.36
LRRK2 Q5S007 1/20 0.36
PNP P00491 1/20 0.36
PDPK1 O15530 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30770845 1.00 ALDH1A1 (0.48) ALDH1A1PRKCIKDM4EMAPTRAD52
SCHEMBL3229989 0.76 KDM4E (0.50) ALDH1A1KDM4EMAPTAPEX1RECQL
SCHEMBL8367003 0.74 KDM4E (0.39) ALDH1A1KDM4EMAPTAPEX1RECQL
SCHEMBL620396 0.74 SMN1; SMN2 (0.48) ALDH1A1KDM4EMAPTTDP1LMNA
SCHEMBL29623085 0.74 KDM4E (0.39) ALDH1A1KDM4EMAPTAPEX1RECQL
SCHEMBL324999 0.74 ALDH1A1 (0.39) ALDH1A1KDM4EMAPTAPEX1RECQL
SCHEMBL8044760 0.74 ALDH1A1 (0.39) ALDH1A1PRKCIKDM4EMAPTRAD52
SCHEMBL324998 0.74 ALDH1A1 (0.39) ALDH1A1KDM4EMAPTAPEX1RECQL
SCHEMBL21906548 0.74 ALDH1A1 (0.39) ALDH1A1KDM4EMAPTAPEX1RECQL
SCHEMBL27796456 0.74 ALDH1A1 (0.39) ALDH1A1PRKCIKDM4EMAPTRAD52

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12503477-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors GENZYME CORPORATION 2025-12-23 US disclosed
US-20240217991-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS GENZYME CORPORATION (US) 2024-07-04 US disclosed
US-11958871-B2 Inhibitors of bacterial glutaminyl cyclases for use in the treatment of periodontal and related diseases Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2024-04-16 US disclosed
US-20220396588-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS GENZYME CORPORATION (US) 2022-12-15 US disclosed
US-11274108-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors GENZYME CORPORATION (US) 2022-03-15 US disclosed
US-20200392174-A1 NOVEL INHIBITORS OF BACTERIAL GLUTAMINYL CYCLASES FOR USE IN THE TREATMENT OF PERIODONTAL AND RELATED DISEASES Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2020-12-17 US disclosed
US-20200392174-A1 NOVEL INHIBITORS OF BACTERIAL GLUTAMINYL CYCLASES FOR USE IN THE TREATMENT OF PERIODONTAL AND RELATED DISEASES Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2020-12-17 US disclosed
EP-3589632-B1 NOVEL INHIBITORS OF BACTERIAL GLUTAMINYL CYCLASES FOR USE IN THE TREATMENT OF PERIODONTAL AND RELATED DISEASES Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung Ev (DE) 2020-09-23 EP disclosed
EP-3589632-B1 NOVEL INHIBITORS OF BACTERIAL GLUTAMINYL CYCLASES FOR USE IN THE TREATMENT OF PERIODONTAL AND RELATED DISEASES Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung Ev (DE) 2020-09-23 EP disclosed
WO-2019162458-A1 NOVEL INHIBITORS OF BACTERIAL GLUTAMINYL CYCLASES FOR USE IN THE TREATMENT OF PERIODONTAL AND RELATED DISEASES Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2019-08-29 WO disclosed
WO-2009111277-A1 IMDIZO [4. 5-B] PYRIDINE DERIVATIVES USED AS RAF INHIBITORS ARRAY BIOPHARMA INC. (US) 2009-09-11 WO disclosed
US-7273863-B1 Benzophenones as inhibitors of reverse transcriptase SMITHKLINE BEECHAM CORPORATION (US) 2007-09-25 US disclosed
EP-1710238-A1 Benzophenones as inhibitors of reverse transcriptase GLAXO GROUP LIMITED (GB) 2006-10-11 EP disclosed
EP-1208091-A1 BENZOPHENONES AS INHIBITORS OF REVERSE TRANSCRIPTASE GLAXO GROUP LIMITED (GB) 2002-05-29 EP disclosed
WO-2001017982-A1 BENZOPHENONES AS INHIBITORS OF REVERSE TRANSCRIPTASE GLAXO GROUP LIMITED (GB) 2001-03-15 WO disclosed
EP-0640084-A4 6-AMINO SUBSTITUTED IMIDAZO 4,5-b]PYRIDINES AS ANGIOTENSIN II ANTAGONISTS. MERCK & CO INC (US) 1995-08-23 EP disclosed
US-5412097-A Heterocyclic compounds bearing acidic functional groups as angiotensin II antagonists MERCK & CO., INC. (US) 1995-05-02 US disclosed
EP-0640084-A1 6-AMINO SUBSTITUTED IMIDAZO 4,5-b]PYRIDINES AS ANGIOTENSIN II ANTAGONISTS MERCK & CO. INC. (US) 1995-03-01 EP disclosed
WO-1993023399-A1 6-AMINO SUBSTITUTED IMIDAZO[4,5-b]PYRIDINES AS ANGIOTENSIN II ANTAGONISTS MERCK & CO., INC. (US) 1993-11-25 WO disclosed
US-5223499-A Hypotensive agents MERCK & CO., INC. (US) 1993-06-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200392174-A1 NOVEL INHIBITORS OF BACTERIAL GLUTAMINYL CYCLASES FOR USE IN THE TREATMENT OF PERIODONTAL AND RELATED DISEASES GMPS, GLS, QPCT ALDH1A1 3918/4885PRKCI 294/4885KDM4E 2350/4885
US-11958871-B2 Inhibitors of bacterial glutaminyl cyclases for use in the treatment of periodontal and related diseases GMPS, GLS, QPCT ALDH1A1 3726/4885PRKCI 333/4885KDM4E 2092/4885
US-11274108-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors CSF1R, CSF3R, IL1RN ALDH1A1 1512/4885PRKCI 2522/4885KDM4E 4101/4885
US-20240217991-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS CSF1R, CSF3R, IL1RN ALDH1A1 1512/4885PRKCI 2522/4885KDM4E 4101/4885
US-20220396588-A1 COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS CSF1R, CSF3R, IL1RN ALDH1A1 1512/4885PRKCI 2522/4885KDM4E 4101/4885
US-12503477-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors CSF1R, CSF3R, IL1RN ALDH1A1 1517/4885PRKCI 2697/4885KDM4E 3985/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.