Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GUSB | P08236 | 3/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044760 | 0.76 | ALDH1A1 (0.39) | KDM4EALDH1A1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL30770845 | 0.76 | ALDH1A1 (0.48) | KDM4EHTTALDH1A1PIK3CDPIK3CA | |
| SCHEMBL8367003 | 0.76 | KDM4E (0.39) | KDM4EALDH1A1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL2190488 | 0.76 | ALDH1A1 (0.48) | KDM4EHTTALDH1A1PIK3CDPIK3CA | |
| SCHEMBL324998 | 0.76 | ALDH1A1 (0.39) | KDM4EALDH1A1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL620396 | 0.76 | SMN1; SMN2 (0.48) | KDM4EHTTALDH1A1PIK3CDPIK3CA | |
| SCHEMBL29623085 | 0.76 | KDM4E (0.39) | KDM4EALDH1A1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL324999 | 0.76 | ALDH1A1 (0.39) | KDM4EALDH1A1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL21906548 | 0.76 | ALDH1A1 (0.39) | KDM4EALDH1A1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL27796456 | 0.76 | ALDH1A1 (0.39) | KDM4EALDH1A1PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3159335-B1 | NOVEL HETEROCYCLIC COMPOUND | DAE WOONG PHARMA (KR) | 2020-04-29 | — | — | EP | disclosed |
| US-10471139-B2 | Toll-like receptor agonists | THE UNIVERSITY OF KANSAS (US) | 2019-11-12 | — | — | US | disclosed |
| US-10081634-B2 | Heterocyclic compound | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2018-09-25 | — | — | US | disclosed |
| EP-3159335-A2 | NOVEL HETEROCYCLIC COMPOUND | Daewoong Pharmaceutical Co., Ltd. (KR) | 2017-04-26 | — | — | EP | disclosed |
| US-20170088551-A1 | NOVEL HETEROCYCLIC COMPOUND | Daewoong Pharmaceutical., Ltd. (KR) | 2017-03-30 | — | — | US | disclosed |
| US-20160166681-A1 | TOLL-LIKE RECEPTOR AGONISTS | THE UNIVERSITY OF KANSAS | 2016-06-16 | — | — | US | disclosed |
| WO-2015023958-A1 | TOLL-LIKE RECEPTOR AGONISTS | THE UNIVERSITY OF KANSAS (US) | 2015-02-19 | — | — | WO | disclosed |
| WO-2010015637-A1 | NEW ANTIVIRAL MODIFIED NUCLEOSIDES | NOVARTIS AG (CH) | 2010-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160166681-A1 | TOLL-LIKE RECEPTOR AGONISTS | TLR1, TLR7, TLR8 | KDM4E 4039/4885HTT 871/4885HSD17B10 2511/4885 |
| US-10471139-B2 | Toll-like receptor agonists | TLR1, TLR7, TLR8 | KDM4E 4039/4885HTT 871/4885HSD17B10 2511/4885 |
| US-10081634-B2 | Heterocyclic compound | AARS1, NSUN3, RNASE1 | KDM4E 3488/4885HTT 366/4885HSD17B10 646/4885 |
| US-20170088551-A1 | NOVEL HETEROCYCLIC COMPOUND | AARS1, TARBP1, NSUN3 | KDM4E 3544/4885HTT 486/4885HSD17B10 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.