Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD4 | P21917 | 4/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYBB | P04839 | 1/20 | 0.40 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.40 |
| ▸ | NOX3 | Q9HBY0 | 1/20 | 0.40 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20230983 | 0.85 | KDM4E (0.51) | MAPTTP53DRD2DRD4HTR7 | |
| SCHEMBL25796945 | 0.78 | HSP90AA1 (0.41) | MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL21664594 | 0.76 | HTR7 (0.47) | MAPTTP53DRD2DRD4HTR7 | |
| SCHEMBL25993141 | 0.71 | ALDH1A1 (0.55) | MAPTDRD2DRD4DRD3NPSR1 | |
| SCHEMBL20230982 | 0.71 | MAPT (0.56) | MAPTTP53DRD2DRD4DRD3 | |
| SCHEMBL20324998 | 0.71 | DRD2 (0.43) | MAPTTP53DRD2DRD4DRD3 | |
| SCHEMBL6029911 | 0.71 | ALDH1A1 (0.67) | MAPTDRD2DRD4HTR7DRD3 | |
| SCHEMBL20234642 | 0.70 | MAPT (0.48) | MAPTTP53DRD2DRD4DRD3 | |
| SCHEMBL20232119 | 0.69 | MAPT (0.50) | MAPTDRD2DRD4DRD3NPSR1 | |
| SCHEMBL20234341 | 0.69 | MAPT (0.50) | MAPTDRD2DRD4HTR7DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10604506-B2 | Modulators of estrogen receptor proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2020-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10604506-B2 | Modulators of estrogen receptor proteolysis and associated methods of use | ADRM1, MDM2, ESR2 | MAPT 2402/4885TP53 45/4885DRD2 4415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.