Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14864328 | 0.77 | ALDH1A1 (0.44) | ALDH1A1HCAR2CA12CA9LMNA | |
| SCHEMBL21164212 | 0.74 | TGM2 (0.47) | ALDH1A1HCAR2CA12CA9LMNA | |
| SCHEMBL8320568 | 0.72 | ALDH1A1 (0.50) | ALDH1A1HCAR2CA12CA9AKR1B10 | |
| SCHEMBL12658032 | 0.69 | ALDH1A1 (0.44) | ALDH1A1HCAR2CA12CA9LMNA | |
| SCHEMBL22394368 | 0.68 | ALDH1A1 (0.55) | ALDH1A1HCAR2CA12CA9AKR1B10 | |
| SCHEMBL17779954 | 0.68 | ALDH1A1 (0.50) | ALDH1A1HCAR2CA12CA9AKR1B10 | |
| SCHEMBL24896641 | 0.68 | ALDH1A1 (0.46) | ALDH1A1HCAR2CA12CA9AKR1B10 | |
| SCHEMBL22716123 | 0.68 | ALDH1A1 (0.59) | ALDH1A1HCAR2CA12CA9AKR1B10 | |
| SCHEMBL17177756 | 0.67 | ALDH1A1 (0.57) | ALDH1A1HCAR2CA12CA9AKR1B10 | |
| SCHEMBL11933629 | 0.67 | ALDH1A1 (0.44) | ALDH1A1HCAR2CA12CA9AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10604506-B2 | Modulators of estrogen receptor proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2020-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10604506-B2 | Modulators of estrogen receptor proteolysis and associated methods of use | ADRM1, MDM2, ESR2 | ALDH1A1 2935/4885HCAR2 1487/4885CA12 3428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.