SCHEMBL219096

SCHEMBL219096

COc1cc(C(=O)Cl)cc(OC)c1OC

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 3/20 0.55
TUBB P07437 3/20 0.55
TUBA3C P0DPH7 3/20 0.55
TUBA1B P68363 3/20 0.55
TUBA4A P68366 3/20 0.55
TUBB4B P68371 3/20 0.55
TUBB3 Q13509 3/20 0.55
TUBB2A Q13885 3/20 0.55
TUBB8 Q3ZCM7 3/20 0.55
TUBA3E Q6PEY2 3/20 0.55
TUBA1A Q71U36 3/20 0.55
TUBA1C Q9BQE3 3/20 0.55
TUBB6 Q9BUF5 3/20 0.55
TUBB2B Q9BVA1 3/20 0.55
TUBB1 Q9H4B7 3/20 0.55
TPMT P51580 1/20 0.53
MAPT P10636 3/20 0.53
LMNA P02545 2/20 0.53
CYP3A4 P08684 1/20 0.52
KMT2A Q03164 4/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28275397 1.00 TUBB4A (0.55) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL28788059 0.91 TUBB4A (0.47) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL11564666 0.91 TUBB4A (0.47) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29728505 0.91 TUBB4A (0.47) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29728503 0.88 TUBB4A (0.45) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL28788063 0.88 TUBB4A (0.45) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL27189692 0.88 ALDH1A1 (0.68) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL14218378 0.88 TPMT (0.47) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL30822595 0.88 ALDH1A1 (0.68) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL7122998 0.87 BPTF (0.53) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1593 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12552931-B2 Dihydroxy lactam based polymers, compositions and applications thereof ISP INVESTMENTS LLC (US) 2026-02-17 US claimed
US-20240400581-A1 Process for Preparing a Macrocyclic Compound Having ENT1 Inhibiting Activity iTeos Belgium SA (BE) 2024-12-05 US claimed
CN-115894386-B 1,2, 3-Triazole compound with IDO1 inhibition function and preparation method thereof 南开大学 2024-10-25 CN claimed
CN-118772131-A Biaryl compound and preparation method and application thereof 河南大学 2024-10-15 CN claimed
CN-118221833-A Functionalized nano-cellulose, preparation method thereof and automobile part 中国第一汽车股份有限公司 2024-06-21 CN claimed
CN-113999126-B Preparation method of trimebutine 浙江东亚药业股份有限公司 2024-05-24 CN claimed
CN-117737998-A Anti-aging polyester filament yarn base cloth 常德天鼎丰非织造布有限公司 2024-03-22 CN claimed
CN-116693524-B Preparation method of bustle 长春迈灵生物工程有限公司 2023-11-03 CN claimed
CN-116693524-A Preparation method of bustle 长春迈灵生物工程有限公司 2023-09-05 CN claimed
CN-115894386-A 1,2,3-triazole compound with IDO1 inhibition function and preparation method thereof 南开大学 2023-04-04 CN claimed
EP-2231151-A2 ANTIFOLATE COMPOUNDS FOR THE TREATMENT OF MELANOMA Universidad de Murcia (ES) 2010-09-29 EP claimed
WO-2009081275-A2 ANTIFOLATE COMPOUNDS FOR THE TREATMENT OF MELANOMA UNIVERSIDAD DE MURCIA (ES) 2009-07-02 WO claimed
US-6214990-B1 2,9-BIS(4-METHOXYBENZOYLOXY),3,10-DIMETHOXY,6,13-DICHLORO -PHENODIOXAZINE, FOR EXAMPLE; DYE HAS NARROW LIGHT ABORPTION BAND AND HIGH DICHROIC RATIO SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-04-10 US claimed
EP-0993436-A1 (S) 2-METHYLAMINO-2-PHENYL-$i(n)-BUTYL 3,4,5-TRIMETHOXYBENZOATE, ITS APPLICATION TO THE TREATMENT OF CHRONIC PAIN PARKE-DAVIS (FR) 2000-04-19 EP claimed
WO-1999001417-A1 (S) 2-METHYLAMINO-2-PHENYL-n-BUTYL 3,4,5-TRIMETHOXYBENZOATE, ITS APPLICATION TO THE TREATMENT OF CHRONIC PAIN PARKE-DAVIS (FR) 1999-01-14 WO claimed
US-4923870-A 2-Carbonyl substituted N,N'-di-(trimethoxygenzoyl)piperazines, process for preparing the same and therapeutical compounds containing them Societe de Conseils de Reserches et d'Applications Scientifiques (FR) 1990-05-08 US claimed
US-4507499-A N-(4-Hydroxybenzyl)-3,4,5-trimethoxybenzamide and method for producing trimethobenzamide chlorohydrate FRANCIS S.P.A. (IT) 1985-03-26 US claimed
EP-0088147-A1 A new compound with analgesic, antiinflammatory and antipyretic activity, process for the preparation thereof and pharmaceutical compositions therefrom AUSONIA FARMACEUTICI S.r.l. (IT) 1983-09-14 EP claimed
EP-0005232-B1 ISOQUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM HOECHST AKTIENGESELLSCHAFT (DE) 1982-08-25 EP claimed
US-4104278-A Process for the production of compounds with antiphlogistic activity TROPONWERKE DINKLAGE & CO. (DE) 1978-08-01 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12552931-B2 Dihydroxy lactam based polymers, compositions and applications thereof PARG, GNE, PGLS TUBB4A 1614/4885TUBB 862/4885TUBA3C 1759/4885
US-20240400581-A1 Process for Preparing a Macrocyclic Compound Having ENT1 Inhibiting Activity ENTPD5, ENTPD1, ENTPD8 TUBB4A 4273/4885TUBB 4379/4885TUBA3C 4402/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.